TGFBR3


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TGFBR3

A gene on chromosome 1p33-p32 that encodes transforming growth factor (TGF)-beta type-III receptor. TGFBR3 is a membrane proteoglycan, which often acts as a co-receptor with other TGF-beta receptors.
 
Molecular pathology
TGFBR3 is downregulated in certain cancers.
References in periodicals archive ?
Consistent t(1;10) with rearrangements of TGFBR3 and MGEA5 in both myxoinflammatory fibroblastic sarcoma and hemosiderotic fibrolipomatous tumor.
TGFBR3 and MGEA5 rearrangements are much more common in "hybrid" hemosiderotic fibrolipomatous tumormyxoinflammatory fibroblastic sarcomas than in classical myxoinflammatory fibroblastic sarcomas: a morphological and fluorescence in situ hybridization study.
Consistent t(1; 10) with rearrangements of TGFBR3 and MGEA5 in both myxoinflammatory fibroblastic sarcoma and hemosiderotic fibrolipomatous tumor.
More recently, Antonescu et al (19) studied a series of 7 cases of MIFS, 14 HFLTs, and 3 neoplasms with mixed morphology, finding consistent t(1; 10) with rearrangements of TGFBR3 and MGEA5 in both MIFS and HFLT.