TGFB3


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TGFB3

A gene on chromosome 14q24 that encodes a member of the transforming growth factor beta (TGFB) family of cytokines. These multifunctional peptides up- and downregulate proliferation, differentiation, adhesion, migration, death and other functions in many cell types. TGFBs transduce their signal by binding to transmembrane growth factor receptors (TGFBR1 and TGFBR2) and their downstream effectors, the SMAD proteins; disruption of the TGFB/SMAD pathway has been implicated in various cancers. TGFB3 is involved in embryogenesis and cell differentiation.

Molecular pathology
TGFB3 mutations cause familial arrhythmogenic right ventricular dysplasia type 1.
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Furthermore, TGFB3 with promoter hyper-methylation was detected in the crossbred group and has been reported to be related with growth in chicken [16].
Several genes were highlighted due to their known association with growth and production, including TGFB3, ACSL1, RYR1, ACOX2, PPARG2, NTN1, RIN2, MAPRE1, ADAMTS2, MYOM1, ZDHHC13, and SH3PXD2B.
MSX1 and TGFB3 Contribute to Clefting in South America.
Some rabbits in the study received a bioscaffold infused with a collagen gel loaded with the protein, called transforming growth factor beta 3 (TGFB3), while other rabbits received bioscaffolds with TGFB3.
Asociation of MSX1 and TGFB3 with nonsyndromic clefting in humans.