TGFB2


Also found in: Acronyms.

TGFB2

A gene on chromosome 1q41 that encodes a member of the transforming growth factor beta (TGFB) family of cytokines. These multifunctional peptides up- and downregulate proliferation, differentiation, adhesion, migration, death and other functions in many cell types. TGFBs transduce their signal by binding to transmembrane growth factor receptors (TGFBR1 and TGFBR2) and their downstream effectors, the SMAD proteins; disruption of the TGFB/SMAD pathway has been implicated in various cancers.
 
Molecular pathology
TGFB2  translocations to HDAC9 on chromosome 7 (t(1;7)(q41;p21)) is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye.
References in periodicals archive ?
They identified variants in two genes, TGFB2 and HMOX that appear to contribute to the development of CM in Angolan children.
082 beta 1 (Camurati-Engelmann disease) transforming growth factor, TGFB2 0.
18) La produccion de LIF es regulada positivamente por los factores de crecimiento TGFBs (Factores Transformantes de Crecimiento tipos Beta: TGFB1, TGFB2 y TGFB3) en las celulas endometriales, los cuales estimulan su produccion e inhiben la produccion del mediador proinflamatorio IL6.