TGFB2

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TGFB2

A gene on chromosome 1q41 that encodes a member of the transforming growth factor beta (TGFB) family of cytokines. These multifunctional peptides up- and downregulate proliferation, differentiation, adhesion, migration, death and other functions in many cell types. TGFBs transduce their signal by binding to transmembrane growth factor receptors (TGFBR1 and TGFBR2) and their downstream effectors, the SMAD proteins; disruption of the TGFB/SMAD pathway has been implicated in various cancers.
 
Molecular pathology
TGFB2  translocations to HDAC9 on chromosome 7 (t(1;7)(q41;p21)) is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye.
References in periodicals archive ?
Teratogenicity of retinoic acid and its effects on TGF-beta2 expression in the developing cerebral cortex of the rat.
When serum was replaced, however, by IGF-1 plus TGF-beta2 an increased glycosaminoglycan production and induction of collagen type II was observed, especially in cells isolated from ear perichondrium.
What's more, through further experiments the researchers found that instead of using the mutated gene to induce the transformation, they could incubate endothelial cells with either one of two specific proteins (growth factors TGF-beta2 and BMP4) whose cellular interactions mimicked the effects of the mutated gene, providing a more efficient way to reprogram the cells.
Possibility of inducing anterior chamber-associated immune deviation by TGF-beta2 treatment of monocytes isolated from Behcet's patients.