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A fluorescence in situ hybridization (FISH) was performed, although TFE3 and TFEB showed no evidence of such gene rearrangements.
By using mouse and human cells upregulated or knocked-down for TFEB expression, the applicant will establish a role for TFEB in exosome biogenesis, cargo selectivity and secretion.
Both TFE3 and TFEB belong to the microphthalmia transcription factor (MiTF) subfamily.
43,44) Both TFEB and TFE3 are members of the MiTF/TFE family of transcription factors.
The fusion gene product TFEB antibody is specific for the t(6;11) translocation carcinomas.
2 locus or the TFEB gene located at the 6p21 locus are a unique--albeit relatively rare--group of renal malignancies.
Renal carcinomas with the t(6; 11)(p21;q12): clinicopathologic features and demonstration of the specific alpha TFEB gene fusion by immunohistochemistry, RT-PCR, and DNA PCR.
The MiTF family of transcription factors includes MiTF, TFE3, TFEB, and TFEC.
42,43) Similarly, TFEB is also a transcription factor that is overexpressed in pediatric RCCs with t(6; 11)(p21; q12).
TFE3 belongs to the same family of transcription factors as MiTF, TFEB and TFEC.
25) Because TFE3 and TFEB translocation RCCs share clinical, morphologic, immunohistochemical, and molecular features, Argani and Ladanyi (5) proposed to regroup these neoplasms under the category MITF/TFE family translocation carcinomas.
2, another variant harboring a different translocation, t(6;11)(p21;12), has been described, which produces a fusion between the Alpha and the TFEB genes.
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