TFAP2A

TFAP2A

A gene on chromosome 6p24 that encodes a member of the AP-2 family of transcription factors, which activate the transcription of genes involved in proper eye, face, body wall, limb and neural tube development. TFAP2A inhibits C/EBP alpha, MCAM/MUC18 and MYC.

Molecular pathology
TFAP2A mutations cause branchiooculofacial syndrome.
References in periodicals archive ?
We added 11 markers [GATA3, GATA binding protein 3; GDNF, glial cell derived neurotrophic factor; OPCML, opioid binding protein/cell adhesion molecule-like; PENK, proenkephalin; TFAP2A, transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha); APP, amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease); CACNA1G, calcium channel, voltage-dependent, T type, alpha 1G subunit; HOXA1, homeobox A1; NEUROG1, neurogenin 1; APBA2, amyloid beta (A4) precursor protein-binding, family A, member 2; and TRRAP, transformation/transcription domain-associated protein on the basis of a study that indicated increased methylated DNA in CRC tissue (19).