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TATA box

   Also found in: Dictionary/thesaurus, Legal, Financial, Encyclopedia, Wikipedia, Hutchinson 0.01 sec.
TATA box
a eukaryotic DNA sequence usually TATAAATA, similar to the Pribnow box of Escherichia coli, occurring in the promoter region 25 to 35 bases upstream from the transcriptional start site that binds the general transcription factor TFIID which begins the formation of the transcription initiation complex which includes RNA polymerase.


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The sequence also has a TATA box located between 15 and 25 nucleotides in the 3' direction of the closest Dof element.
Once the transcription factors bind to the TATA box the genes start making mRNA.
[41] However, Hoechst 33342-induced apoptosis is associated with mitochondrial dysfunction,[41] inhibition of endogenous topoisomerase I activity,[25,26,40,41] and decreased formation of normal TATA box-binding protein/ TATA box complexes,[24,27] suggesting that Hoechst 33342-induced apoptosis is associated with a novel mechanism.
 
 
 
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