TAL1


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TAL1

A gene on chromosome 1p32 that encodes a protein which may play a key role in haematopoietic differentiation.
 
Molecular pathology
Defects in TAL1 may cause T-cell acute lymphoblastic leukaemia (T-ALL), in which there is a translocation t(1;14) (p32;q11) with T-cell receptor alpha chain (TCRA).
References in periodicals archive ?
These genes include TAL1 and RUNX1, both of which are essential for the development of blood stem cells, and hence to human life.
The relatively commonly occurring t(1;14)(p34;q11) translocation observed in 3% of T- ALL results in the transposition of TAL1 proto-oncogene from its normal position on chromosome 1 into the T-cell receptor (Alpha) / (standard devotions) chain complex on chromosome 14.
Additionally, some T- ALL patients have been identified with local rearrangements of the TAL1 locus that are not detectable by karyotype analysis.
T-cell ALL cells undergo site-specific genetic alterations in the TAL1 gene due to problematic activity of the enzyme recombinase, and as a result, a truncated protein with oncogenic activity is produced (43).
She has studied how the oncogenes TAL1 and NOTCH1 cooperate to cause T-ALL.
Primers and protocols for standardized detection of minimal residual disease in acute lymphoblastic leukemia using immunoglobulin and T cell receptor gene rearrangements and TAL1 deletions as PCR targets: report of the BIOMED-1 CONCERTED ACTION: investigation of minimal residual disease in acute leukemia.
Primers and protocols for standardized detection of minimal residual disease in acute lymphoblastic leukemia using immunoglobulin and T-cell receptor gene rearrangement and TAL1 deletions as PCR targets: report of the BIOMED1 CONCERTED ACTION: investigations of minimal residual disease in acute leukemia.