MAP3K7

(redirected from TAK1)
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MAP3K7

A gene on chromosome 6q15 that encodes a MAPK kinase kinase belonging to a protein kinase signal transduction cascade. MAP3K7 plays a key role in the cascades of cellular responses triggered by environmental changes, as well as ceramides. It mediates signal transduction of TRAF6; various cytokines, including IL1; transforming growth factor-beta (TGFB), and TGFB-related factors like BMP2 and BMP4; toll-like receptors (TLR); tumour necrosis factor receptor CD40; and B-cell receptor (BCR). Once activated, MAP3K7 acts as an upstream activator of the JNK and the P38 signal transduction cascades by phosphorylating and activating several MAP kinase kinases.

Each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of three protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which in turn activates a specific MAPK.
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Alternately, when TAK1 is increased, the satellite cells prosper.
TAK1 and TRAF6 support distinct functions that regulate satellite cell survival and functionality.
Considerable more work will be needed to fully understand the critical pathways involved, but it is our hope that TAK1 inhibitors will ultimately be developed for clinical testing," he added.
2009) Helicobacter pylori CagA activates NF-kB by targeting TAK1 for TRAF6-mediated Lys 63 ubiquitination.
51) TRIF recruits TRAF6 and activates TAK1 for NF-[kappa]B activation through ubiquitination dependent mechanisms similar to those of the MyD88 dependent pathway.
Gamma-tocotrienol inhibits nuclear factor-kappaB signaling pathway through inhibition of receptor-interacting protein and TAK1 leading to suppression of antiapoptotic gene products and potentiation of apoptosis.
Through GPR120, n-3 PUFAs inhibit the activation and phosphorylation of TAK1 by the [beta]-arrestin2/TAB1 dependent effect, resulting in the inhibition of TNF-a and TLR inflammatory signaling pathways [61].
In this study, the up-regulation of SOD2 and the down-regulation of BID and TAK1 by glycyrrhizin, silymarin, and ursodeoxycholic acid suggested the anti-oxidative properties of these compounds.
1996) TAB1: an activator of the TAK1 MAPKKK in TGF-[beta] signal transduction.
33) JNK pathway is activated by a large number of external stimuli, and the initial signaling pathway starts with the activation of several MAPKKKs including TAK1, MEKK1/4, MLK-2 and -3, and ASK1, which phosphorylate MEK4 or MEK7 and induce the activation of JNK.
2007) and phosphorylation of p38 MAPK induced the activation of Runx2 via TAK1 and MEK3 signal pathway during early osteoblastic differentiation (Greenblatt et al.