Ambulatory ECG-based T-wave alternans
and heart rate turbulence can predict cardiac mortality in patients with myocardial infarction with or without diabetes mellitus.
(TWA) is a non-invasive marker of the vulnerability to ventricular arrhythmia (1).
Now, doctors have completed the first systematic test of using T-wave alternans
for making decisions about implanting defibrillators.
would have tremendous implications for the cost-benefit ratio of this form of treatment," noted the cardiologist at a session on T-wave alternans
Tests to identify a subset of patients who may not actually need or profit from a device--that would have tremendous implications for the cost-benefit ratio of this form of treatment," noted the cardiologist, who cochaired a session on T-wave alternans
Studies show that heart patients with this electrical change, called T-wave alternans
, face a much greater risk of arrhythmia and SCD than do those without the underlying disorder.
The results of this study further demonstrate the predictive power of our Microvolt T-Wave Alternans
technology" said David Chazanovitz, president andCEO of Cambridge Heart, "We would anticipate that both physicians and payers would view these study results as a demonstration of the important role MTWA testing can play in both increasing the effectiveness of ICD therapy and controlling costs.
Such a propensity to develop T-wave alternans
is considered a harbinger of the problem that defibrillators protect against.
Considering all of the above, the microscopic T-wave alternans
(MTWA) seems to be a good criterion for conducting risk stratification analysis.