T-cell receptor

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T-cell re·cep·tor

(TCR) (sel rĕ-sep'tŏr)
An adhesion molecule on the membrane of T lymphocytes, which serves as the receptor for antigen bound to antigen-presenting cells (APC) through MHC molecules. It is expressed in a complex with CD3. It is in proximity to the MHC-restricted receptor (CD4 or CD8).
Synonym(s): T-lymphocyte antigen receptor.

T-cell receptor

Abbreviation: TCR
One of two polypeptide chains (a or ß) on the surface of T lymphocytes that recognize and bind foreign antigens. TCRs are antigen specific; their activity depends on antigen processing by macrophages or other antigen-presenting cells and the presence of major histocompatibility complex proteins to which peptides from the antigen are bound.
See: autoimmunity; immune response; T cell
See also: receptor
References in periodicals archive ?
T-cell receptor gamma gene rearrangement by multiplex polymerase chain reaction/heteroduplex analysis in patients with cutaneous T-cell lymphoma (mycosis fungoides/Sezary syndrome) and benign inflammatory disease: correlation with clinical, histological and immunophenotypical findings.
In a further study published in the Journal of Biological Chemistry the same Cardiff and King's team has shown that this focused binding mode allows this T-cell receptor to respond to over 1.
T-cell receptor gene rearrangement analysis by PCR on extracted DNA from intestinal biopsies is an alternative method of identifying a T-cell clone, as in this case report.
United Kingdom-based GSK has exercised the option to receive an exclusive global license from Adaptimmune for an investigational SPEAR T-cell receptor therapy aimed at tumour antigen, NY-ESO-1 (GSK3377794), it was reported on Friday.
6,16,20-22) A clonal T-cell receptor gene rearrangement is detected in 54% to 100% of cases, (10,15,17-23,26) but immunoglobulin heavy-chain (IgH) rearrangements are polyclonal.
Researchers used a T-cell receptor from a cancer patient cloned by other scientists that seeks out an antigen expressed by this type of melanoma.
The PCR-based test for SCID is based on looking for a minimum number of T-cell receptor excision circles (TRECs) within naive T cells.
Immunoglobulin and T-cell receptor (TCR) gene rearrangements are frequently used as targets in PCR-based MRD studies (15-18).
The latest results supporting this optimism are new data indicating that scavenger cells called macrophages secrete a chemical that disintegrates other cells and McFarlin's preliminary discovery that multiple sclerosis patients have a "peculiar pattern of T-cell receptor gene.
The Novartis Prize for Basic Immunology 2016 is shared by John Kappler (National Jewish Health, USA), Philippa Marrack (National Jewish Health, USA) and Harald von Boehmer (Emeritus, Harvard Medical School, USA) for their work in demonstrating how the immune system is able to discriminate "self" from "non-self" through a process in the thymus based on positive and negative selection via T-cell receptor mediated recognition of peptide-MHC complexes.
Then, in 1985, Isaacson and colleagues (3) used immunohistochemistry and T-cell receptor gene rearrangement studies as evidence that celiac-associated lymphoma is of T-cell origin.

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