T-cell lymphomas

lymphoma /lym·pho·ma/ (lim-fo´mah) any neoplastic disorder of lymphoid tissue. Often used to denote malignant l., classifications of which are based on predominant cell type and degree of differentiation; various categories may be subdivided into nodular and diffuse types depending on the predominant pattern of cell arrangement.

adult T-cell lymphoma , adult T-cell leukemia/lymphoma see under leukemia.

B-cell lymphoma any in a large group of non-Hodgkin's lymphomas characterized by malignant transformation of the B lymphocytes.

B-cell monocytoid lymphoma a low-grade lymphoma in which cells resemble those of hairy cell leukemia.

Burkitt's lymphoma a form of small noncleaved-cell lymphoma, usually occurring in Africa, manifested usually as a large osteolytic lesion in the jaw or as an abdominal mass; Epstein-Barr virus has been implicated as a causative agent.

centrocytic lymphoma mantle cell l.

convoluted T-cell lymphoma lymphoblastic lymphoma with markedly convoluted nuclei.

cutaneous T-cell lymphoma a group of lymphomas exhibiting (1) clonal expansion of malignant T lymphocytes arrested at varying stages of differentiation of cells committed to the series of helper T cells, and (2) malignant infiltration of the skin, which may be the chief or only manifestation of disease.

diffuse lymphoma in an older classification method, malignant lymphoma in which the neoplastic cells diffusely infiltrate the entire lymph node, without any definite organized pattern.

follicular lymphoma any of several types of non-Hodgkin's lymphoma in which the lymphomatous cells are clustered into nodules or follicles.

follicular center cell lymphoma B-cell lymphoma classified by the similarity of the cell size and nuclear characteristics to those of normal follicular center cells; the four previous subtypes are scattered among several types of follicular and diffuse lymphomas.

giant follicular lymphoma follicular l.

granulomatous lymphoma Hodgkin's disease.

histiocytic lymphoma a rare type of non-Hodgkin's lymphoma characterized by the presence of large tumor cells resembling histiocytes morphologically but considered to be of lymphoid origin.

Hodgkin's lymphoma see under disease.

intermediate lymphocytic lymphoma , lymphocytic lymphoma, intermediately differentiated mantle cell l.

large cell lymphoma any of several types of lymphoma characterized by the formation of one or more types of malignant large lymphocytes, such as large cleaved or noncleaved follicular center cells, in a diffuse pattern.

large cell, immunoblastic lymphoma a highly malignant type of non-Hodgkin's lymphoma characterized by large lymphoblasts (B or T lymphoblasts or a mixture) resembling histiocytes and having a diffuse pattern of infiltration.

Lennert's lymphoma a type of non-Hodgkin's lymphoma with a high content of epithelioid histiocytes and frequently with bone marrow involvement.

lymphoblastic lymphoma a highly malignant type of non-Hodgkin's lymphoma composed of a diffuse, relatively uniform proliferation of cells with round or convoluted nuclei and scanty cytoplasm.

malignant lymphoma a group of malignancies characterized by the proliferation of cells native to the lymphoid tissues, i.e., lymphocytes, histiocytes, and their precursors and derivatives; the group is divided into two major clinicopathologic categories: Hodgkin's disease and non-Hodgkin's lymphoma.

mantle cell lymphoma , mantle zone lymphoma a rare form of non-Hodgkin's lymphoma having a usually diffuse pattern with both small lymphocytes and small cleaved cells.

marginal zone lymphoma a group of related B-cell neoplasms that involve the lymphoid tissues in the marginal zone, the patchy area outside the follicular mantle zone.

mixed lymphocytic-histiocytic lymphoma non-Hodgkin's lymphoma characterized by a mixed population of cells, the smaller cells resembling lymphocytes and the larger ones histiocytes.

nodular lymphoma follicular l.

non-Hodgkin's lymphoma a heterogeneous group of malignant lymphomas, the only common feature being an absence of the giant Reed-Sternberg cells characteristic of Hodgkin's disease.

plasmacytoid lymphocytic lymphoma a rare variety of small lymphocytic lymphoma in which the predominant cell type is the plasma cell.

primary effusion lymphoma a B-cell lymphoma associated with human herpesvirus 8 infection, characterized by the occurrence of lymphomatous effusions in body cavities without the presence of a solid tumor.

small B-cell lymphoma the usual type of small lymphocytic lymphoma, having predominantly B lymphocytes.

small cleaved cell lymphoma a group of non-Hodgkin's lymphomas characterized by the formation of malignant small cleaved follicular center cells, with either a follicular or diffuse pattern.

small lymphocytic lymphoma a diffuse form of non-Hodgkin's lymphoma representing the neoplastic proliferation of well-differentiated B lymphocytes, with focal lymph node enlargement or generalized lymphadenopathy and splenomegaly.

small lymphocytic T-cell lymphoma small lymphocytic lymphoma that has predominantly T lymphocytes.

small noncleaved cell lymphoma a highly malignant type of non-Hodgkin's lymphoma characterized by the formation of small noncleaved follicular center cells, usually in a diffuse pattern.

T-cell lymphomas a heterogeneous group of lymphoid neoplasms representing malignant transformation of the T lymphocytes.

U-cell lymphoma , undefined lymphoma a category of non-Hodgkin's lymphomas that cannot be classified into a definite type by either morphologic or known immunocytochemical markers.

undifferentiated lymphoma small noncleaved cell l.

T-cell lymphomas,

a heterogenous group of lymphoid tumors representing malignant transformation of the T lymphocytes. Some types of tumors formerly included in this group have been found to be mixtures of T cells and B cell precursors.

T-cell lymphoma

A malignant proliferation of T cells arising in the skin, diagnosed by detecting rearrangement of the T-cell receptor's β chain; TCLs are often 'driven' by EBV and other viral infections; 90% of all Pts with TCL have extracutaneous involvement when diagnosed. See Mycosis fungoides.

T-cell lymphomas

Small lymphocytic (well-differentiated lymphocyte-like) lymphoma–13%

Convoluted cell lymphoma or poorly-differentiated lymphocytic lymphoma–52%

Immunoblastic sarcoma or 'histiocytic' lymphoma–19%

Mycosis fungoides/Sézary syndrome–11%

Lymphoepithelial cell (Lennert's) lymphoma–5%

Cutaneous T-cell lymphoma

HTLV (I, II)–induced lymphoma

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adult T-cell lymphoma African lymphoma B-cell lymphoma Burkitt's lymphoma Cutaneous T-Cell Lymphoma diffuse large B-cell lymphoma diffuse lymphoma follicular lymphoma giant follicular lymphoma intermediate lymphocytic lymphoma large cell lymphoma Lennert's lymphoma lymphadenoma lymphoblastic lymphoma lymphoblastoma lymphoma malignant lymphoma Mantle Cell Lymphoma nodular lymphoma			T-Cell Proliferations Extranodal T-cell lymphomas comprise a diverse group of neoplasms derived from postthymic T cells, which vary considerably in geographic incidence, age at presentation, clinical and morphologic presentation, as well as immunophenotype and molecular abnormalities. Small lymphoid proliferations in extranodal locations by Rao, Dinesh S.; Said, Jonathan W. / Archives of Pathology & Laboratory Medicine Recent studies have suggested a role for HTLV (human T-cell leukemia/lymphoma virus) in cutaneous T-cell lymphomas. The chronic leukemias of lymphoid origin, part 1 by Rector, James T.; Schumacher, Harold R.; Cotelingam, James D. / Medical Laboratory Observer Both B-cell and T-cell lymphomas in this setting share the property of demonstrating evidence of Epstein-Barr virus (EBV) infection in a substantial proportion of cases. Natural killer--like T-cell lymphoma of the parotid in a patient ... by Cornfield, Dennis B.; Papiez, Joseph S.; Lynch, James T.; Rimsza, Lisa M. / Archives of Pathology & Laboratory Medicine			T helper cell T lymphocyte t statistic t test T tube T tube cholangiography T tubule T tubule system T wave T zone T&A T&S t'ai ch'i t'ai chi T-1824 T-3 T-4 cell T-ACE T-binder T-box T-box genes T-butylaminoethanol T-cell antigen receptor T-cell immunodeficiency syndrome T-cell lymphoma T-cell lymphomas T-cell mediated hypersensitivity T-cell-mediated hypersensitivity reaction T-cell-mediated immunity t-distribution T-helper cell T-helper cells T-independent antigen T-max T-mycoplasma T-on-P phenomenon t-PA t-plasminogen activator T-shaped fracture T-spine t-strain mycoplasma T-TAC t-test T-wave alternans T. anseris T. oertli T.D. t.d.s t.d.s. T.D.X. t.i.d			T-Carrier Restoration Control Center T-carrier system T-CATTS T-CCS T-CCT T-cell T-cell T-cell T-cell acute lymphoblastic leukemia T-Cell Acute Lymphoblastic Lymphoma T-cell antigen receptor T-cell antigen receptor T-Cell Antigen Receptor Complex, Epsilon Subunit of T3 T-Cell Antigen Receptor, Beta Subunit T-Cell Clonopathy of Undetermined Significance T-Cell Colony Growth T-cell Death Associated Gene 51 T-cell Dependant Antibody Response T-cell Epitopes associated with Impaired Peptide Processing T-Cell Growth Factor T-cell immunodeficiency syndrome T-cell l T-cell l T-cell l T-Cell Laboratory-Adapted T-Cell Leukemia, Homeobox T-Cell Lymphoblastic Lymphoma T-cell lymphoma T-cell lymphoma T-cell lymphoma T-cell lymphomas T-Cell Lymphosarcoma Cell Leukemia T-Cell Malignant Lymphoma T-cell mediated hypersensitivity T-cell mediated immunity T-cell mediated immunity T-cell mediated immunity T-Cell Phenotype Modifier 1 T-Cell Prolymphocytic Leukaemia T-Cell Protein Tyrosine Phosphatase T-Cell Rearrangement Excision Circle T-cell receptor T-cell receptor T-cell receptor alpha T-Cell Receptor Alpha Delta T-Cell Receptor Alpha Variable T-cell Receptor B Variable T-Cell Receptor Beta Genes T-Cell Receptor Delta T-cell Receptor Excision Circle T-Cell Receptor Gamma-Variable T-Cell Receptor Variable T-Cell Receptor Variable Beta T-cell response T-cell response T-cell response T-Cell Tat-Associated Kinase T-Cell-Depleted Marrow T-cell-mediated hypersensitivity reaction T-cell-mediated immunity