systemic sclerosis

Systemic sclerosis

A rare disorder that causes thickening and scarring of multiple organ systems.

Mentioned in: Scleroderma

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systemic sclerosis,

a form of scleroderma characterized by formation of thickened collagenous fibrous tissue, thickening of the skin, and adhesion of the skin to underlying tissues. The disease, which may be preceded by Raynaud's phenomenon, progresses to involve the tissues of the heart, lungs, muscles, genitourinary tract, and kidneys. See also scleroderma.

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sclerosis [sklĕ-ro´sis]

an induration or hardening, especially of a part from inflammation, or in disease of the interstitial substance. The term is used chiefly for such a hardening of the nervous system due to hyperplasia of the connective tissue or for hardening of the blood vessels. Called also induration. adj., adj sclerot´ic.

amyotrophic lateral sclerosis see amyotrophic lateral sclerosis.

arteriolar sclerosis arteriolosclerosis.

disseminated sclerosis multiple sclerosis.

familial centrolobar sclerosis a progressive familial form of leukoencephalopathy marked by nystagmus, ataxia, tremor, parkinsonian facies, dysarthria, and mental deterioration.

focal glomerular sclerosis focal segmental glomerulosclerosis.

glomerular sclerosis glomerulosclerosis.

hippocampal sclerosis loss of neurons in the region of the hippocampus, with gliosis; sometimes seen in epilepsy.

lateral sclerosis a form seated in the lateral columns of the spinal cord. It may be primary, with spastic paraplegia, rigidity of the limbs, and increase of the tendon reflexes but no sensory disturbances, or secondary to myelitis, with paraplegia and sensory disturbance.

medial calcific sclerosis (Mönckeberg's sclerosis) Mönckeberg's arteriosclerosis.

multiple sclerosis see multiple sclerosis.

systemic sclerosis systemic scleroderma.

tuberous sclerosis a congenital heredofamilial disease, transmitted as an autosomal dominant trait, characterized principally by the presence of hamartomas of the brain (tubers), retina (phakomas), and viscera, mental retardation, seizures, and adenoma sebaceum, and often associated with other skin lesions.

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systemic sclerosis

Scleroderma Rheumatology An idiopathic connective tissue disease with clinical and pathologic features of GVHD, characterized by subcutaneous and visceral fibrosis, anticentromere and antitopoisomerase antibodies and prominent microvascular changes with endothelial cell damage and proliferation of subendothelial connective tissue; ♀:♂ ratio, 3-8:1-after child-bearing yrs Peak Age 45 to 55. See Connective tissue disease, Graft-versus-host disease.