Syntocinon


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Related to Syntocinon: Misoprostol, Ergometrine, Terbutaline

oxytocin

Pitocin, Syntocinon (CA) (UK), Syntometrine (UK)

Pharmacologic class: Posterior pituitary hormone

Therapeutic class: Uterine-active agent

Pregnancy risk category NR

FDA Box Warning

• Drug isn't indicated for elective induction of labor (defined as initiation of labor in pregnant woman with no medical indications for induction). Available data aren't adequate to evaluate benefits versus risk.

Action

Unknown. Thought to directly stimulate smooth muscle contractions in uterus and cervix.

Availability

Injection: 10 units/ml ampule or vial

Indications and dosages

To induce or stimulate labor

Adults: Initially, 1-ml ampule (10 units) in compatible I.V. solution infused at 1 to 2 milliunits/minute (0.001 to 0.002 units/minute). Increase rate in increments of 1 to 2 milliunits/minute q 15 to 30 minutes until acceptable contraction pattern is established.

To control postpartum bleeding

Adults: 10 to 40 units in compatible I.V. solution infused at rate adequate to control bleeding; or 10 units I.M. after placenta delivery

Incomplete abortion

Adults: 10 units in compatible I.V. solution infused at 10 to 20 milliunits/minute (0.01 to 0.02 units/minute)

Off-label uses

• Antepartal fetal heart rate testing
• Breast enlargement

Contraindications

• Hypersensitivity to drug
• Cephalopelvic disproportion
• Fetal distress when delivery is not imminent
• Prolonged use in uterine inertia or severe toxemia
• Hypertonic or hyperactive uterine pattern
• Unfavorable fetal position or presentation that's undeliverable without conversion
• Labor induction or augmentation when vaginal delivery is contraindi-cated (as in invasive cervical cancer, active genital herpes, or total placenta previa)

Precautions

Use cautiously in:
• previous cervical or uterine surgery, history of uterine sepsis
• breastfeeding patients.

Administration

• Reconstitute by adding 1 ml (10 units) to 1,000 ml of normal saline solution, lactated Ringer's solution, or dextrose 5% in water.

Don't give by I.V. bolus injection.
• Infuse I.V. using controlled-infusion device.
• Be aware that drug isn't routinely given I.M.
• Know that drug should be given only to inpatients at critical care facilities when prescriber is immediately available.

Adverse reactions

CNS: seizures, coma, neonatal brain damage, subarachnoid hemorrhage

CV: premature ventricular contractions, arrhythmias, neonatal bradycardia

GI: nausea, vomiting

GU: postpartal hemorrhage; pelvic hematoma; uterine hypertonicity, spasm, or tetanic contraction; abruptio placentae; uterine rupture (with excessive doses)

Hematologic: afibrinogenemia

Hepatic: neonatal jaundice

Other: hypersensitivity reactions including anaphylaxis, low 5-minute Apgar score (neonate)

Interactions

Drug-drug.Sympathomimetics: postpartal hypertension

Thiopental anesthetics: delayed anesthesia induction

Vasoconstrictors: severe hypertension (when given within 3 to 4 hours of oxytocin)

Drug-herbs.Ephedra (ma huang): increased hypertension

Patient monitoring

Continuously monitor contractions, fetal and maternal heart rate, and maternal blood pressure and ECG. Discontinue infusion if uterine hyper-activity occurs.

Monitor patient extremely closely during first and second stages of labor because of risk of cervical laceration, uterine rupture, and maternal and fetal death.
• When giving drug to control postpartal bleeding, monitor and record vaginal bleeding.
• Assess fluid intake and output. Watch for signs and symptoms of water intoxication.

Patient teaching

• Inform patient about risks and benefits of oxytocin-induced labor.

Teach patient to recognize and immediately report adverse drug effects.

Syntocinon

a trademark for an oxytocic (oxytocin).

Syntocinon

A brand name for the womb muscle stimulating drug OXYTOCIN.
References in periodicals archive ?
She said: "The use of the drug Syntocinon is common in obstetrics when labour is prolonged, but in this case, when there were clear signs of feotal distress, it was a catastrophic decision and one which contravened the guidelines of Royal College of Obstetricians and Gynaecologists.
Syntocinon is a synthetic form of the hormone oxytocin, which helps to stimulate muscles to produce contractions.
Martha Okuonghae, 51, attempted on several occasions to administer more than 10 times the correct dose of labourinducing drug syntocinon into a drip, a conduct committee heard.
When Lynn's waters broke and she failed to progress in her labour, medics gave her Syntocinon, which is used to induce labour.
Following the delivery of a healthy live female infant, intravenous boluses of cephazolin 2 g and syntocinon 5 IU were given, and an infusion of syntocinon 10 IU/hour was commenced.
Martha Okuonghae, 51, who had worked at Merthyr Tydfil's Prince Charles Hospital between 2005 and 2006, admitted attempting to give 10 times the correct amount of labour-inducing drug syntocinon to her patients.
Generally when we consider clinical interventions we discuss practices such as artificial rupture of the membranes (ARM), intravenous syntocinon to accelerate labour, epidural anaesthesia, instrumental and caesarean births (Tracy, 2006).
Syntocinon - one of the hormones used to induce contractions - can cause stress for the baby and make contractions more painful.
Nurses with North Glamorgan NHS Trust gave evidence yesterday to the Nursing and Midwifery Council hearing that the midwife attempted on several occasions to administer more than 10 times the correct dose of syntocinon - a labour-inducing drug - into an IV drip.