gene synthesis

(redirected from Synthetic gene)

gene synthesis

the artificial construction of a gene from OLIGONUCLEOTIDES by chemical means.
References in periodicals archive ?
Nobel Prize winner Har Gobind Khorana, an Indian-American biochemist who was credited with discovery of essential function of the DNA and construction of the first synthetic gene, was honored by Google in form of a doodle on Tuesday.
The company is developing two propriety technology platforms: synNotch, a synthetic gene expression system that responds to external cues which, among other applications, can be deployed to engineer chimeric antigen receptor T (CAR T) cells that require dual antigen recognition for activation, and Throttle, an "on switch" that modulates CAR T activity using small molecules.
The company's platform overcomes the current inefficiencies of synthetic DNA production, and enables cost-effective, rapid, high-quality and high throughput synthetic gene production, which in turn, expedites the design, build and test cycle to enable personalized medicines, pharmaceuticals, sustainable chemical production, improved agriculture production, diagnostics, and biodetection.
Data shows that Anc80-AAV, an in silico-designed synthetic gene therapy vector, has the potential to provide superior gene expression levels in retina, liver, muscle, cochlea's outer hair cells and other tissue targets in preclinical studies, as well as reduced cross-reactivity as compared to naturally occurring adeno-associated viral vectors (AAVs) that are currently in clinical development.
Synthetic gene and the bacterial expression vector (pET-15b) were digested with NdeI and BamHI enzymes (Fermentas, EU), and the ligation step was performed using Rapid DNA Ligation Kit (Fermentas, EU).
In Fussenegger's opinion, it is a real breakthrough that a synthetic gene network has been successfully used to achieve genetic reprogramming that delivers beta cells.
The synthetic gene and pJIT163 vector were restricted with EcoRI and HindIII (Fermentas) restriction enzymes at 37C for 1 h.
Synthetic Gene Network: Modeling, Analysis, and Robust Design Methods
Washington, Oct 16 ( ANI ): A new research has found that a synthetic gene module controlled by the happiness hormone dopamine produces an agent that lowers blood pressure.
Arctic Apples will be generally equivalent to regular apples, except for a synthetic gene that is a duplicate of its own genes which activates a self-defense mechanism known as RNA interference that shuts down the genes responsible forthe production of discoloration-causingpolyphenol oxidase.
With the gene machine, it was possible to create a synthetic gene, put it in an E.
The fragments reduce the cost for synthetic gene synthesis by eliminating expensive complexity fees and long delivery times.