5], Neurogenesis, axonal remodeling, synaptogenesis
, and increased vascularization may contribute to the chronic therapeutic effects of fornix DBS.
Synaptamide is synthesized from DHA in the brain, although it binds weakly to cannabinoid receptors, it independently stimulates growth, synaptogenesis
and synaptic activity in developing hippocampal neurons at nano-molar concentrations.
The brain contains approximately 25% of the body's unsterified cholesterol, and cholesterol has functionally important roles in steroidogenesis, synaptogenesis
and synaptic plasticity, neurotransmission at G-protein coupled receptors, myelin production, the structure of neuronal and vesicular membranes, and the regulation of cortical serotonin systems (Dietschy & Turley, 2001; Jafurulla & Chattopadhyay, 2013; Miller & Auchus, 2011; Qiu, Korwek, & Weeber, 2006; Vance, Hayashi, & Karten, 2005).
It has been demonstrated in rats and mice that during motor skill learning, reorganization and expansion occurs in the related motor cortex region where movement is represented in the primary motor cortex and an increased complexification and cortical synaptogenesis
develop in the dendritic spines of the pyramidal neurons (24).
NMDA receptor modulation activates the mTORC1 signaling pathway, which is required to initiate the cellular processes like protein synthesis that lead to the synaptogenesis
and antidepressant effects of these agents.
Zinc has been shown to be essential for neurogenesis, neuronal migration, and synaptogenesis
Learning causes synaptogenesis
, whereas motor activity causes angiogenesis, in cerebellar cortex of adult rats.
1) In the mammalian forebrain, synaptogenesis
starts before birth, but the number of synapses significantly increases in the early postnatal period.
I don't think we know enough yet to say that nutrients in themselves support neurogenesis (the growth of neurons) and synaptogenesis
(the growth of neural connections)," Greenwood said.
Molecular neurorestorative mechanisms include neurogenesis, angiogenesis, synaptogenesis
, and trophic factor secretion.
Osteopontin expression in acute immune response mediates hippocampal synaptogenesis
and adaptive outcome following cortical brain injury.
These processes include precursor cell proliferation, neuronal and glial cell differentiation and apoptosis, synaptogenesis
and myelination, and are also termed "key biological processes" or "key neurodevelopmental events".