Detection of recurrent thyroid cancer by sensitive nested reverse transcriptionpolymerase chain reaction of thyroglobulin and sodium/iodide symporter
messenger ribonucleic acid transcripts in peripheral blood.
and iodine into the thyroid follicular cells is active transport.
Immunohistochemical profile of the sodium/iodide symporter
in thyroid, breast, and other carcinomas using high density tissue microarrays and conventional sections.
Wild-type p53 enhances the cytotoxic effect of radionuclide gene therapy using sodium iodide symporter
in a murine anaplastic thyroid cancer model.
In addition to the thyroid, other organs have a sodium-iodide symporter
A sodium iodide symporter
is genetically fused to either the N-terminus or C-terminus of the product of a transgene through a linker peptide which bears the recognition sequence of a host cell protease.
3] The sodium/iodide symporter
involved in the concentration of iodide in the thyroid gland has been sequenced and cloned.
University of Increased Radioisotope California Uptake in Non-Small Cell Los Angeles Lung Cancer Following Transfection with Sodium/ Iodide Symporter
Gene Michael Nishimura, Ph.
Of these, thyroid peroxidase and sodium iodide symporter
are key proteins in the metabolic pathway of TH.
This molecule is called the sodium iodide symporter
(abbreviated NIS; a symporter
is a protein embedded in a cell's membrane that helps to move several different molecules or ions into the cell).
Several proteins mediating iron uptake into cells have been identified, including the ubiquitously expressed transferrin receptor 1, which binds iron complexed to transferrin (31); transferrin receptor 2, the expression of which is restricted to hepatocytes, duodenal crypt cells, and erythroid precursors; divalent metal transporter 1, a H+/divalent metal symporter
found in duodenal enterocytes, which mediates uptake of dietary iron (32,33); cubilin, a protein expressed in polarized epithelial cells in the kidney, which mediates endocytosis of iron and transferrin with its coreceptor megalin (34); and the hemoglobin scavenger receptor CD163, which is expressed on the surface of monocytes and macrophages and receives plasma hemoglobin bound to haptoglobin.
(NIS) (15-17), thyroglobulin (TG) (18-21 ), thyroperoxidase (TPO) (22-24), dual oxidase 2 (DUOX2; also known as ThOX2 and LNOX2) (25), and Pendrine (PDS; also known as SLC26A4) (26, 27) genes.