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The randomised, double-blind, parallel-group, 24-week, chronic-dosing, multi-centre trial assessed the efficacy and safety of PT010, comparing it to Bevespi Aerosphere (glycopyrronium/formoterol fumarate), Symbicort Turbuhaler (budesonide/formoterol fumarate), and PT009 (budesonide/formoterol fumarate, characterised to qualify as a relevant competitor in clinical trials for PT010).
AstraZeneca PLC has been cleared by the Food and Drug Administration to update the label for Symbicort inhalation aerosol (budesonide/formoterol fumarate dihydrate), including removal of the boxed warning for serious asthmarelated outcomes.
Advair (fluticasone propionate/salmeterol; GSK): Advair and Symbicort have similar NPS scores.
For years, Spiriva (Pfizer), Advair (GSK), and Symbicort (AstraZeneca) controlled the vast majority of the COPD market, and few companies made serious inroads into new research.
Medications included SymbiCort Turbuhaler, tiotropium bromide, and salbutamol sulfate aerosol.
Formoterol is also found in the combination product Symbicort, which combines formoterol and budesonide as a HFA metered dose inhaler.
The asthma drugs are formoterol (Foradil, Perforomist, Symbicort, Dulera), albuterol, levalbuterol, metaproterenol, pirbuterol (Maxair), and terbutaline.
This is in spite of generic erosion facing several of the leading asthma brands, such as Advair (fluticasone propionate/salmeterol xinafoate), Symbicort (budesonide/formoterol fumarate) and Xolair (omalizumab), and is a consequence of new market entrants and rising disease prevalence.
Pfizer proposes using some of that money overseas, along with shares of its stock, to pay for AstraZeneca, maker of cholesterol drug Crestor and asthma treatment Symbicort.
In Germany, for example, the system of reference pricing led to major price cuts in July for both GSK's lung drug Viani -- also known as Advair or Seretide -- as well as AstraZeneca's rival Symbicort.
His medications included aspirin, clopidogrel, symbicort, metoprolol, simvastatin and frusemide.
The inhaled corticosteroids evaluated were fluticasone, sold in combination with salmeterol as Advair, and budesonide, sold in combination with formoterol as Symbicort.