Swainsona


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Swainsona

Australian genus of plants in the legume family Fabaceae, closely related to Astragalus; contain the toxic indolizidine alkaloid swainsonine which causes tremor, incoordination, mania and death from an acquired lysosomal storage disease through inhibition of α-mannosidase so that mannose accumulates in nervous and other tissues. Toxic species include S. brachycarpa (small-flowered Darling pea), S. canescens (gray Swainson pea), S. galegifolia (smooth Darling pea), S. greyana (Darling pea), S. luteola (dwarf Darling pea), S. procumbens (Broughton pea), S. swainsonioides. See also mannosidosis, astragalus, swainsonine, lysosomal storage diseases.