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Swainsona

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Swainsona
Australian genus of plants in the legume family Fabaceae, closely related to Astragalus; contain the toxic indolizidine alkaloid swainsonine which causes tremor, incoordination, mania and death from an acquired lysosomal storage disease through inhibition of α-mannosidase so that mannose accumulates in nervous and other tissues. Toxic species include S. brachycarpa (small-flowered Darling pea), S. canescens (gray Swainson pea), S. galegifolia (smooth Darling pea), S. greyana (Darling pea), S. luteola (dwarf Darling pea), S. procumbens (Broughton pea), S. swainsonioides. See also mannosidosis, astragalus, swainsonine, lysosomal storage diseases.
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It was used to study glucoprotein N-link oligosaccharide as an instrument drug, since it was separated initially from the fruit of Australian Swainsona canescens and North America locoweed (including Astragalus and Oxytropis spp.
Inhibition of the growth of human gastric carcinoma in vivo and in ... by Sun, J.-Y.; Zhu, M.-Z.; Wang, S.-W.; Miao, S.; Xie, Y.-H.; Wang, J.-B. / Phytomedicine: International Journal of Phytotherapy & Phytopharmacology
One example is the once widespread, endangered plant, Swainsona recta (the small purple pea), which survives only in fragmented grasslands and woodlands along roadsides, railway easements and within reserves.
Patch genetics; Steve Davidson finds genetic clues for conservation by Ecos
 
 
 
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