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surfactant replacement therapy

   Also found in: Acronyms 0.01 sec.
surfactant replacement therapy
Neonatology Intratracheally administered bronchoalveolar fluid derived from calves–98% lipids, comprised of 90% phospholipid, especially dipalmitoyl-phosphatidylcholine and 2% apoproteins, which markedly improves gas exchange in premature infants; prophylactic bovine surfactant administered intratracheally ↓ need for neonatal respiratory support and ↑ survival of premature infants, especially < 30 wks. See Hyaline membrane disease.


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Future Directions of Surfactant In addition to RDS of the newborn, surfactant replacement therapy has been considered in meconium aspiration syndrome.
While all exogenous surfactants reduce RDS and hence RDS-related complications, since the advent of surfactant replacement therapy in the 1980s mortality in these infants most often results from non-pulmonary conditions related to preterm birth (intraventricular hemorrhage, necrotizing enterocolitis, infection, etc.
The current standard of care for treating these patients is Surfactant Replacement Therapy using animal-derived surfactants.
 
 
 
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