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suramin

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suramin [soo´rah-min]
an antifilarial and antiprotozoal agent used as the hexasodium salt in prophylaxis and treatment of early stages of African trypanosomiasis and sometimes onchocerciasis. Because of its toxicity it must be used with care.
suramin
a trypanocidal agent that is also toxic, causing degeneration of the liver, kidney and adrenal glands. It is also an inhibitor of reverse transcriptase, some types of growth factors, and causes suppression of the adrenal cortex, leading to investigations of its usefulness in the treatment of immunodeficiency infection in humans and cats, cancer and hyperadrenocorticism.
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Evaluation of prostate-specific antigen as a surrogate marker for response of hormone-refractory prostate cancer to suramin therapy.
A rapid PSA half-life following docetaxel chemotherapy is associated ... by Hanninen, Mikael; Venner, Peter; North, Scott / Canadian Urological Association Journal (CUAJ)
12) and excoriations against Eye involvement microfilaria with gradual Adjunctive impairment of doxycycline vision and sterilises female blindness (river worm blindness) Add systemic steroids in cases of eye involvement Suramin for adult worms Loiasis (Fig.
Parasitic infections may be confined to the skin or may have skin ... by Modi, Deepak / CME: Your SA Journal of CPD
Suspect Drugs Chemotherapy Agents Associated With Neurotoxicity Combination of methotrexate*, cyclophosphamide, and fluorouracil* Vinca alkaloids Cytarabine Platinum analogues Ifosfamide Taxol Taxotere Fludarabine Suramin Agents Associated With Occasional Reports of Cognitive or Motor Impairment L-asparagine Busulfan Hexamethylmelamine Procarbazine Thiotepa *Also associated with cognitive impairment individually.
Chemotherapy may affect aspects of neuropsychological function by MacReady, Norra / Clinical Psychiatry News
 
 
 
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