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Sumoylation

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Sumoylation
The covalent attachment of a small ubiquitin-related modifier (SUMO) to substrate protein, a process that is biochemically analogous to, but functionally distinct from, ubiquitination; sumoylation is critical to many different biological processes—e.g., protein localisation and stability, transcriptional activities, nucleocytoplasmic signalling and transport, genome replication, and regulation of gene expression


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The latest research for examining constitutive heterochromatin, pathology-related inclusions and sumoylation are also discussed.
Liu could force cells in his lab to go through the ubiquitination or sumoylation process to show how p53 molecules were affected.
The team suggests that clumping renders the mutant form of huntingtin harmless, but that sumoylation makes the protein soluble and thus toxic.
 
 
 
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