sulfonylurea /sul·fo·nyl·urea/ (sul″fŏ-nil-u-re´ah) any of a class of compounds that exert hypoglycemic activity by stimulating the islet tissue to secrete insulin; used to control hyperglycemia in patients with type 2 diabetes mellitus who cannot be treated solely by diet and exercise.
sulfonylurea
sul·fo·nyl·u·re·a (s l f -n l-y -r  )n. Any of a group of hypoglycemic drugs, such as tolbutamide, that act on the beta cells of the pancreas to increase the secretion of insulin. |
sulfonylurea
[sul′fənilyoo͡r′ē·ə]
an oral antidiabetic agent that stimulates the pancreatic production of insulin. Hypersensitivity to sulfonamides is a contraindication for using such agents, and ethanol consumption is incompatible with all sulfonylureas. These agents cross the placenta, and their use has been associated with a higher incidence of birth defects, making insulin the preferred drug in treating diabetes in pregnancy. Aspirin or other salicylates taken with any sulfonylurea may intensify the hypoglycemic effect.
sulfonylurea
a class of chemical compounds that includes the oral hypoglycemic agents acetohexamide, chlorpropamide, tolazamide and tolbutamide.
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