According to the widely accepted hypothesis, hyperkinetic movement disorders occur due to the loss of subthalamic
nucleus control on the internal segment of the globus pallidus (GPi), which leads to disinhibition of the thalamus.
Fully automated targeting using nonrigid image registration matches accuracy and exceeds precision of best manual approaches to subthalamic
deep brain stimulation targeting in Parkinson disease.
Frank, "Hold your horses: A dynamic computational role for the subthalamic
nucleus in decision making," in Neural Networks, vol.
nucleus deep brain stimulation in a patient with cervical dystonia and essencial tremor.
nucleus deep brain stimulation: Summary and meta-analysis of outcomes.
Beneficial Effects of Bilateral Subthalamic
Stimulation on Non-Motor Symptoms in Parkinson's Disease.
The effect of the lesioning procedures, such as pallidotomy (lesioning in the globus pallidus) or subthalamic
nucleotomy (lesioning in the STN), is immediate and permanent in most instances.
The role of the subthalamic
nucleus in the preparation of volitional movement termination in Parkinson's disease," Experimental Neurology, vol.
deep brain stimulation, which is commonly conducted on PD patients with motor complications that are resistant to antiparkinsonian medication, was claimed to be harmful for semantic and verbal fluency as well as executive profiles by a meta-analysis .
While the association between subthalamic
nucleus deep brain stimulation (STN-DBS) and DDS is not fully known, a probable mechanism is abnormal dopamine oscillation to the nucleus accumbens and overstimulation of the mesolimbic system (2).
Increased intracranial pressure which develops after head trauma causes an increase in the activity of the sympathetic nervous system and an increase in serum catecholamine levels by directly or indirectly stimulating the hypothalamic or subthalamic
Electrical stimulation of a deep-seated brain region, the subthalamic
nucleus (STN), has been shown to significantly improve patients motor function and quality of life.