subacute combined degeneration

subacute combined degeneration Subacute combined degeneration of the spinal cord Neurology A disorder caused by vitamin B₁₂ deficiency, characterized by weakness, sensory defects, mental changes, vision defects, often associated with megaloblastic anemia Clinical SCD causes demyelination, affecting the spinal cord, brain, optic and peripheral nerves, with axonal destruction. See Vitamin B₁₂ deficiency.