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matrix metalloproteinase |
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matrix metalloproteinase,
any of a group of endopeptidases that hydrolyze proteins of the extracellular matrix. Want to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit the webmaster's page for free fun content. |
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1188 ing to their substrate specificity, primary structure, and cellular localization, these enzymes can be divided into at least five different subfamilies of closely related members known as collagenases, gelatinases, stromelysins, matrilysins, and membrane-type MMPs (reviewed in Murphy et al, 2002). Thus stromelysin 3 (MMP11) is associated with the invasive phase of breast cancer, and much effort has been put into trying to design compounds that inhibit MMPs with a view to inhibiting tumour invasion. ; decreased platelet-derived growth factor (PDGF); decreased basic fibroblast growth factor (b-FGF); increased keratan sulfate; increased stromelysin; increased ratio of stromelysin to tissue inhibitor of metalloproteases (TIMP); increased osteocalcin; increased alkaline phosphatase; increased cAMP responsive to hormone challenge; increased urokinase plasminogen activator; increased cartilage oligomeric matrix protein; and increased collagenase. |
Stromelysin |
stromatolite Stromatolites Stromatolites stromatolith stromatolitic stromatolitic Stromatology Stromatoporoid Stromatoporoidea stromatosis Stromb Strombacea Strombidae Strombidae Strombite Stromboid Stromboli Stromboli Stromboli Island Stromboli Island Strombolian Strombolian Strombolian eruption Strombolian eruption Strombuliform Strombus Strombus Strombus Strombus gigas Stromectol Stromelysin Stromelysin-3Stromeyerite Stromeyerite Stromgen Strömgren four-color index Stromgren radius Strömgren radius Stromgren sphere Strömgren sphere Strömgren Spheres Stromgren, Svante Elis Strömgren, Svante Elis Stromile Swift Strominger-Yau-Zaslow Stromkarl Stromkarl Stromkarl Strömkarl Strömkarl Strömkarl Strömming Strömming Stromness Strømø Stromotion stromuhr Stronazon Strond strong strong | ||||||||
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