Rapamycin, an antifungal, anticancer, and immune-suppressing compound secreted by the bacterium Streptomyces hygroscopicus
, is the basis for an anti-aging drug being developed by the Swiss pharmaceutical company Novartis.
Sirolimus is a macrolide-group antibiotic that is isolated from Streptomyces hygroscopicus
Igarashi Y, T Iida R, Yoshida and T Furumai Pteridic acids A and B, novel plant growth promoters with auxin-like activity from Streptomyces hygroscopicus
For example, rapamycin, an immune-suppressor used to prevent transplant rejection, is produced by the bacterium Streptomyces hygroscopicus
Azalomycin F complex from Streptomyces hygroscopicus
, MSU/MN-4-75 B.
Hygromycin B is a potent product of Streptomyces hygroscopicus
that acts as an antibiotic against both prokaryotic and eukaryotic organisms (1), (2).
Sirolimus a macrocyclic lactone produced by Streptomyces hygroscopicus
which is a potent immunosuppressive agent.
The active ingredient is pimecrolimus, which is derived from ascomycin, a natural substance produced by the fungus Streptomyces hygroscopicus
The drug is derived from the soil bacterium Streptomyces hygroscopicus
, native to the island of Rapa Nui (Easter Island).
Sirolimus (Rapamune[R] rapamycin) is a macrocyclic lactone produced by Streptomyces hygroscopicus
tumefaciens) and bar (phosphinotricin acetyltransferase from Streptomyces hygroscopicus
, another soil bacterium) with terminator 3'g7 (source unspecified) both under the control of the bidirectional TR1/2 promoter (from A.
Sirolimus was isolated in the 1970's from Streptomyces hygroscopicus
in soil samples from Easter Island.