steroidogenic factor 1


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steroidogenic factor 1 (SF-1),

orphan nuclear receptor that participates in organogenesis of adrenals, gonads, and pituitary. Deficient SF-1 has been associated with adrenal insufficiency and sexually ambiguous genitalia.
References in periodicals archive ?
In this article we address the role of the important transcription factor, steroidogenic factor 1 (SF-1), in atrazine-induced aromatase expression.
Steroidogenic factor 1, an orphan nuclear receptor, regulates the expression of the rat aromatase gene in gonadal tissues.
1,8) Three main pathways appear relevant: a prolactin-GH-thyroidstimulating hormone (TSH) pathway regulated by transcription factor Pit-1, (9-11) a gonadotroph pathway regulated by steroidogenic factor 1 (SF-1), (12,13) and a corticotroph pathway mediated by T-box transcription factor (Tpit).
Key words: amphibians, bullfrogs, octylphenol, sexual differentiation, steroidogenic factor 1.
Sexual dimorphic expression of steroidogenic factor 1 (SF-1)in developing gonads of the American bullfrog, Rana catesbeiana.
Recent studies have shown the transcription factor steroidogenic factor 1 is an extremely sensitive marker at identifying adrenal cortical neoplasms (ranging from 85% to 100%) and, furthermore, exhibits 100% specificity at discriminating these neoplasms from other tumors with clear cell morphology, such as renal cell carcinoma, ovarian clear cell carcinoma, and chordomas (176,177) This nuclear marker is identified at high levels in sex cord-stromal tumors of the ovary and at lower levels in testicular sex cord-stromal tumors.
Malignant tumors with clear cell morphology: a comparative immunohistochemical study with renal cell carcinoma antibody, Pax8, steroidogenic factor 1, and brachyury.
Sex cord stromal tumors are usually negative for these germ cell markers and positive for steroidogenic factor 1 (SF1), inhibin-[alpha], calretinin, and forkhead box L2 (FOXL2).
In gynecologic pathology, the loss of p57 expression in the villous cytotrophoblasts and stromal cells is a characteristic feature of complete moles; hepatocyte nuclear factor 1b (HNF1[beta]) is a useful marker for identifying clear cell carcinoma of the uterus and ovary and is usually negative in papillary serous carcinoma; pVHL and kidney injury molecule 1 (KIM-1) have been reported to be helpful in the distinction between clear cell carcinoma of the uterus and ovary from serous carcinoma; forkhead box L2 (FOXL2) and steroidogenic factor 1 (SF-1) have been reported to be sensitive and specific markers for sex cord stromal tumors.
24) The positivity for other adrenal cortical markers such as a-inhibin, calretinin, synaptophysin, and steroidogenic factor 1 or the absence of premelanosomes can be of additional help for the differentiation of adrenal cortical neoplasm from EAML.