Consensus Statement 2: At a minimum, review all available slides for high-grade squamous intraepithelial lesion
(HSIL) Pap tests with negative biopsies, with a correlation interval between 3 to 4 months but not exceeding 6 months.
Women 18-60 years old agreed to be followed over the course of the 5-year study to determine the main predictors of cytologic progression to squamous intraepithelial lesions
(SIL) from ASCUS, Dr.
Atypical squamous cells, cannot exclude a high-grade squamous intraepithelial lesion
and its clinical significance in postmenopausal, pregnant, postpartum, and contraceptive-use patients.
At our institution, most high-grade squamous intraepithelial lesions
(HSILs) corresponding to cervical intraepithelial neoplasia (CIN) II and III are treated by loop electrosurgical excision procedure (LEEP).
More recently, the terms low-grade (LSIL) and high-grade squamous intraepithelial lesion
(HSIL) have been proposed for squamous lesions of the penis .
Sherman ME, Schiffman M, Cox JT; Atypical Squamous Cells of Undetermined Significance/Low-Grade Squamous Intraepithelial Lesion
Triage Study Group.
Unfortunately, the present testing and scoring paradigm does not use the current evidence-based paradigm in the screening, diagnosis, and follow-up of cervical neoplasia, particularly in the separation of low-grade squamous intraepithelial lesions
(LSILs) and high-grade squamous intraepithelial lesions
Loop electrosurgical excision for high grade squamous intraepithelial lesion
cervical cytology at Nakornping Hospital.
Concordance Rates for Target Diagnoses of Low-Grade Squamous Intraepithelial Lesion
(LSIL), High-Grade Squamous Intraepithelial Lesion
(HSIL), and Squamous Cell Carcinoma (SCC) by Year Target Diagnosis 2006 2007 LSIL concordance rate, 967 (79.
7) ASCUS = atypical squamous cells of undetermined significance; LSIL = low-grade squamous intraepithelial lesion
; HSIL = high-grade squamous intraepithelial lesion
high-grade squamous intraepithelial lesion
or greater [HSIL+]) and histology (cervical intraepithelial neoplasia 2 or greater [CIN-2+]), in HIV-infected women (n = 420) and HIV-uninfected women (n = 279).
Comparison of the Bethesda and the British Society for Clinical Cytology (BSCC) classification systems for cervical cytology (8) Bethesda classification BSCC classification Negative for intraepithelial lesion or malignancy Negative Unsatisfactory for evaluation Inadequate Atypical squamous cells of undetermined Borderline significance (ASC-US) nuclear change Atypical squamous cells cannot exclude H-SIL (ASC-H) Atypical endocervical, endometrial or glandular cells (not otherwise specified or specify) Atypical endocervical or glandular cells favour neoplasia Low-grade squamous intraepithelial lesion
(L-SIL) Mild dyskaryosis High-grade squamous intraepithelial lesion
(H-SIL) Moderate dyskaryosis Severe dyskaryosis Squamous cell carcinoma Severe dyskaryosis ?