squalene epoxidase

(redirected from Squalene monooxygenase)
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squa·lene e·pox·i·dase

an enzyme that catalyzes the conversion of squalene to squalene 2,3-oxide in the endoplasmic reticulum; a required step in order for cyclization to occur, resulting in the synthesis of the first sterol, lanosterol, in steroidogenesis; uses NADPH.
References in periodicals archive ?
Laden and Porter (2001) have shown that resveratrol reduced cholesterol synthesis by inhibiting squalene monooxygenase in vitro, a rate-limiting enzyme in cholesterol biosynthesis.
61,74) Androgen ablation-resistant tumors were shown to be more strongly immunoreactive for squalene monooxygenase than were androgen-dependent tumors.