alternative splicing

(redirected from Splice form)

alternative splicing

different ways of assembling exons to produce different mature mRNAs.

al·ter·na·tive splic·ing

(awl-tĕr'nă-tiv splīs'ing)
Different ways of assembling exons to produce different mature mRNAs.

alternative splicing

process in which RNA PRIMARY TRANSCRIPTS (containing INTRONS as well as EXONS) of some genes give rise to related, but different, mature mRNAs, by differences in RNA SPLICING so that different combinations of exons assemble. This increases the coding capacity of the GENOME and results in the synthesis of a range of related PROTEINS, called isoforms. Alternative splicing is also called DIFFERENTIAL SPLICING.
References in periodicals archive ?
Evidence that public database records for many cancer-associated genes reflect a splice form found in tumors and lack normal splice forms.
For example, a study examining the effects of alternative splicing on transcripts encoding membrane proteins revealed that a common splice form leads to the removal of the transmembrane domain of single-pass transmembrane proteins, producing a soluble protein isoform (30).
The technology's single primer strategy requires only one partner exon to be targeted, thus allowing identification of known fusion events and discovery of new gene fusions and alternative splice forms.
The AgDscam gene has 101 protein-coding regions, called exons, that can be spliced together in different combinations to produce over 31,000 possible splice forms that function as receptors.
The identification of novel splice forms and their gene expression patterns has begun to be a significant area of drug discovery research.
The research team utilised quantitative real-time polymerase chain reaction to evaluate the expression of telomerase reverse transcriptase (TERT), splice forms and telomere length, while the activity of telomeres was assessed by enzyme-linked immunosorbent assay (ELISA).
Alternative splicing is largely responsible for the proteomic complexity of the approximately 30,000-40,000 genes in the human genome; 40-60 percent of human genes have alternative splice forms.