mitotic spindle

(redirected from Spindle apparatus)
Also found in: Dictionary, Encyclopedia, Wikipedia.

spindle

 [spin´d'l]
1. a pin tapered at one end or both ends, or something with this shape.
2. the thin, tapering figure occurring during metaphase of cell division, composed of microtubules radiating from the centrioles and connecting to the chromosomes at their centromeres. Called also mitotic spindle.
mitotic spindle spindle (def. 2).
muscle spindle a mechanoreceptor found between the skeletal muscle fibers; the muscle spindles are arranged in parallel with muscle fibers, and respond to passive stretch of the muscle but cease to discharge if the muscle contracts isotonically, thus signaling muscle length. The muscle spindle is the receptor responsible for the stretch or myotatic reflex.
sleep s's bursts of activity of a particular waveform in the electroencephalogram in light or early sleep.

mi·tot·ic spin·dle

the fusiform figure characteristic of a dividing cell; it consists of microtubules (s. fibers), some of which become attached to each chromosome at its centromere and are involved in chromosomal movement; other microtubules (continuous fibers) pass from pole to pole.
Synonym(s): nuclear spindle

mitotic spindle

See spindle.

mi·tot·ic spin·dle

(mī-tot'ik spin'dĕl)
The fusiform figure characteristic of a dividing cell; it consists of microtubules (spindle fibers), some of which become attached to each chromosome at its centromere and appear to be involved in chromosomal movement; other microtubules (continuous fibers) pass from pole to pole.
Synonym(s): nuclear spindle.
References in periodicals archive ?
Based on their observations, the team derived a simple mathematical model describing the relationship between the size and shape of the spindle apparatus and the density and amount of microtubules.
In Anaphase, Any chromosome fragment or whole chromosomes which lack a centromere may not be integrated in the nucleus, because of the lack of an indispensable element for orientation in the spindle apparatus.
Within each cell, Xkid molecules are located inside the spindle apparatus, a structure required for cell division that's composed of a bundle of microtubules.
CP461) resulting from both the pro-apoptotic activity of exisulind and antiproliferative activity gained by interfering with the normal function of the spindle apparatus employed by cells during cell division; and -- Agents like CP248, still in preclinical development, whose enhanced anticancer activity is due to a different dual mechanism of action: the combination of exisulind's pro-apoptotic activity with antiproliferative activity achieved by the drug's interfering with proper microtubule formation.