SP1

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SP1

Abbreviation for stimulatory protein 1.

SP1

A gene on chromosome 12q13.1 that encodes a transcription factor  which up- or downregulates transcription in response to physiological and pathological stimuli. SP1 binds with high affinity to GC-rich motifs and regulates expression of an array of genes involved in various cell processes, including growth, differentiation, immune responses and apoptosis; it may have a role in modulating cell responses to DNA damage and is implicated in chromatin remodelling. SP1 is highly regulated by post-translational modification—e.g., phosphorylation, sumoylation, proteolytic cleavage, glycosylation and acetylation.