SON

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SON

A gene on chromosome 21q22.11 that encodes an RNA-binding protein which acts as a mRNA splicing cofactor by promoting efficient splicing of cell cycle and DNA-repair transcripts (e.g., TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A and FANCG), which possess weak splice sites. SON also binds to DNA and may indirectly repress hepatitis-B virus (HBV) core promoter activity, as well as transcription of HBV genes and production of HBV virions.
References in periodicals archive ?
Both thinkers use Genesis in their arguments, analyzing and interpreting its narrative representation of sonship beginning with Adam, and both focus on younger sons in their discussion of primogeniture.
This is the moment where the concept of sonship steps in, because the relation between the divine realm and the human realm may take the form of a relation concerning a divine Father, a divine or a higher Son, and the humans, who are considered the lower "sons.
At least this reader had hoped, perhaps unrealistically, for more analysis of De filiatione Dei itself and of the Cusan sermons that address the topic of sonship and deification.
Indeed it appears in almost all the works ascribed to him and serves both as a word for adoptive sonship in a theological context and as a relative noun in grammatical references.
Paul, in the only passage where he looks at whether his arguments against requiring Torah observance of gentile converts lead to the conclusion that God has revoked his Covenant with the Jews, emphatically answered that it could not: "Theirs is the sonship, the glory and the covenants" (Romans 9:4).
The proprietor worries that the wake is "'costing us money,'" further revealing the economic basis of his relationship with Red and others, while Gene manages to recall sonship, thus recalling the family and the basis of relationship traditionally established through the marriages so defunct in the novel.
A second problem is that despite Bloom's assurance that style does not count much as an indicator of deep indebtedness to one's mentor and therefore should not be invoked in dealing with the Hardy-Shelley sonship struggle, "During Wind and Rain" does seem to owe a good deal to Shelley's style, both for better and for worse.
While the review concerns itself more with Albert's sonship than with his fatherhood, it is evident that the father-son tie has deep importance on both the personal and the national level.
concentrated instead on Hamlet's sonship and the multiple fathers
In a larger theological perspective, though Joyce might treat Catholic doctrine derisively, and in varying degrees blasphemously, he could simultaneously, if not consistently, take its content respectfully, incorporating it into his reflections on the things that concerned him most: the doctrine of transubstantiation, for example, when dealing in Portrait with the artist's power to change the elements of common life into art, or the processions of the Trinity, when pondering in Ulysses the nature of fatherhood and sonship.
In Shakespeare's dark conceit, King Henry VIII as Oberon claims James VI as his surrogate son and heir as he did not (and, as regards sonship, could not) in his 1546 will and testament.