SHH

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SHH

A gene on chromosome 7q36 that encodes a protein central in early embryonic patterning and the key inductive signal in patterning of the anterior-posterior limb axis, the ventral somites and the ventral neural tube.

Molecular pathology
Defects in SHH or in its signalling pathway cause holoprosencephaly, VACTERL syndrome; mutation upstream of SHH disrupts limb patterning and can result in preaxial polydactyly.
References in periodicals archive ?
The team's latest research, he says, is also the first strong evidence that in multiple sclerosis, targeting part of the sonic hedgehog pathway has a fundamentally different effect than blocking the entire pathway, which in other experiments elsewhere did not produce any remyelination but instead halted oligodendrocyte maturation.
Sonic hedgehog, it turns out, floats up to a cell and docks with another protein called Patchedl in a cilium's outer membrane.
This discovery about sonic hedgehog could be applicable not only to erectile dysfunction after prostate surgery but also when the cavernous nerve is damaged by diabetes, which also causes erectile dysfunction," said principal investigator Carol Podlasek, assistant professor of urology at Feinberg.
By examining gene expression in embryos of both fish types, Jeffery's team found that the blind fish express sonic hedgehog and a second gene, tiggy-winkle hedgehog, in a larger region of the body than sighted fish do.
Sonic hedgehog is expressed along the entire length of the embryonic neural tube, the structure that develops into the central nervous system.
NASDAQ: CRIS), a therapeutic drug development company, today announced the publication of preclinical data in the journal Circulation, showing that topical Sonic Hedgehog gene therapy accelerated wound healing in an animal model of diabetes.
Jeffery's team had previously shown that a protein called sonic hedgehog drives eye degeneration in cavefish embryos.
During embryonic development, the gene sonic hedgehog participates in the formation of the brain, heart, lung, skeleton, and many other tissues and organs.
from the Regenerative BioScience Center at the University of Georgia, grew NIH-approved human embryonic stem cells in culture and induced them to differentiate into motor neuron cells by adding basic fibroblast growth factor, sonic hedgehog protein, and retinoic acid to the culture medium.
8 Cell their discovery that proteins from three genes--activin receptor IIa (cAct-RIIa), sonic hedgehog (Shh), and chicken nodal-related 1 (cNR-1)--form a sort of two-pronged biochemical cascade.
Intriguingly, exposure after sonic hedgehog had already established itself in the divided brain affected only the embryo's face, and holding off just a bit longer resulted in no detectable malformation of either brain or beak.