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Sonic Hedgehog Gene

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Sonic Hedgehog Gene
The vertebrate homologue of hedgehog, a Drosophilia—fruitfly—gene that ensures correct embryonic development. SHH products form a molecular gradient which determines which cells will emerge from the CNS during development. Toxins interfering with cholesterol metabolism in vertebrate embryos may cause cyclopia/holoprosencephaly. SHH is mutated in foetuses with holoprosencephaly type 3
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NASDAQ: CRIS), a therapeutic drug development company, today announced the publication of preclinical data in the journal Circulation, showing that topical Sonic Hedgehog gene therapy accelerated wound healing in an animal model of diabetes.
Topical Hedgehog Agonist Accelerates Wound Healing in Diabetes by Business Wire
The scientists believe that HPE may arise from a combination of a faulty sonic hedgehog gene, present from conception, and varying times of exposure to environmental factors that further compromise the protein's signaling.
Stanford Researcher's Findings May Shed Light on Common, Deadly Birth ... by Business Wire
 
 
 
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