Sonic Hedgehog Gene

The vertebrate homologue of hedgehog, a Drosophilia—fruitfly—gene that ensures correct embryonic development. SHH products form a molecular gradient which determines which cells will emerge from the CNS during development. Toxins interfering with cholesterol metabolism in vertebrate embryos may cause cyclopia/holoprosencephaly. SHH is mutated in foetuses with holoprosencephaly type 3
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The genetic change means the Sonic hedgehog gene, which also controls the development of many organs, flickers only briefly when the embryo is only 24 hours old and then goes out at the point when limbs develop.
The Sonic Hedgehog Genes Johns Hopkins University's Roger Reeves, Ph.