somatomedin (redirected from Somatomedins)

somatomedin /so·ma·to·me·din/ (so?mah-to-me´din) any of a group of peptides found in plasma, complexed with binding proteins; they stimulate cellular growth and replication as second messengers in the somatotropic actions of growth hormone and also have insulin-like activities. Two such peptides have been isolated, insulin-like growth factors I and II.

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so·mat·o·me·din (s-mt-mdn, sm-t-)

n.

A peptide synthesized in the liver, capable of stimulating certain anabolic processes in bone and cartilage, and whose secretion and biological activity are dependent on somatotropin. Also called insulinlike growth factor.

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somatomedin

any of a group of peptides found in the liver and in plasma which mediate the effect of growth hormone (somatotropin) on cartilage; they are responsible for uptake of sulfate and increased synthesis of collagen and other proteins by cartilage.

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somatomedin C

participates in the limitation of secretion of growth hormone by the pituitary; produced in various tissues, especially liver; called also IGF-1 or insulin-like growth factor.