AnaptysBio's SHM-XEL platform has pioneered the use of in vitro somatic hypermutation
for antibody discovery, which is designed to replicate key features of the human immune system and overcomes limitations of prior antibody technologies.
However, some lower eukaryotes that evolved before the emergence of immunity also possess specialised polymerases, indicating that they did not all evolve primarily to support somatic hypermutation
or class switching.
The immunophenotypic profile of LPL/WM in combination with the presence of somatic mutations of genes in the immunoglobulin heavy-chain variable region without intraclonal diversity suggests that the malignant cells originate from cells at a late stage of differentiation derived from a B cell arrested after somatic hypermutation
in the germinal center and before terminal differentiation to a plasma cell.
is, in part, responsible, for affinity maturation during an immune response.
H] families, which have also undergone somatic hypermutation
allow the immune system to explore local areas around a specific antibody by making small steps towards an antibody with higher affinity.
Aberrant somatic hypermutation
in tumor cells of nodular-lymphocyte-predominant and classic Hodgkin lymphoma.
Muira and Nakano (no affiliations given) have edited these articles on such topics as somatic hypermutation
, structural chromosomal aberrations and the mechanics of discrimination in DNA repair.
Deficiency of somatic hypermutation
of the antibody light chain is associated with increased frequency of severe respiratory tract infection in common variable immunodeficiency.
is a privately-held company focused on the generation of antibody therapeutics, and the leader in the use of somatic hypermutation
(SHM) for antibody discovery and optimization.
The contributors review research findings on protein tyrosine phosphatases, interleukin-21, class switch recombination, thymus organogenesis, somatic hypermutation
, and T follicular helper cells.
H]) genes have shown the presence of somatic hypermutation
in both benign and malignant monocytoid/marginal zone B cells.