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Somatic gene therapy

   Also found in: Dictionary/thesaurus, Encyclopedia, Wikipedia, Hutchinson 0.01 sec.
Somatic gene therapy
The introduction of genes into tissue or cells to treat a genetic related disease in an individual.
Mentioned in: Gene Therapy


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The invention also provides improved methods for somatic gene therapy capitalizing on enhanced gene transfer, hematopoietic cellular populations, and novel constructs for enhancing retroviral-mediated DNA transfer into cells and their use.
In 1985, the US National Institutes of Health (NIH) approved somatic gene therapy trials, but said that it would not accept proposals for germline manipulation "at present.
[5,7-13] Genetic treatment strategies (pharmacogenetics) may include use of antisense oligonucleotides designed to bind to a region of a gene or messenger RNA to block transcription or translation or somatic gene therapy to transfer and express an exogenous normal gene into a patient's somatic cells.
 
 
 
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