carisoprodol

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carisoprodol

 [kar″i-so´pro-dol]
an analgesic and skeletal muscle relaxant used to relieve symptoms of acute painful skeletomuscular disorders, administered orally.

carisoprodol

Soma

Pharmacologic class: Carbamate derivative

Therapeutic class: Centrally acting skeletal muscle relaxant

Controlled substance schedule IV (in some states)

Pregnancy risk category C

Action

Unknown. May modify central perception of pain without modifying pain reflexes. Skeletal muscle relaxation may result from sedative properties or from inhibition of activity in descending reticular formation and spinal cord.

Availability

Tablets: 250 mg, 350 mg

Indications and dosages

Adjunctive treatment of muscle spasms associated with acute painful musculoskeletal conditions

Adults: 350 mg P.O. q.i.d.

Relief of discomfort associated with acute painful musculoskeletal conditions

Adults: 250 to 350 mg P.O. t.i.d. and at bedtime

Contraindications

• Hypersensitivity to drug or meprobamate
• Porphyria or suspected porphyria

Precautions

Use cautiously in:
• severe hepatic or renal disease
• history of substance abuse
• pregnant or breastfeeding patients
• children ages 12 and younger.

Administration

• Give last daily dose at bedtime.
• Administer with food if GI upset occurs.
• If patient can't swallow tablets, mix with syrup, chocolate, or jelly.

Adverse reactions

CNS: dizziness, drowsiness, agitation, ataxia, depression, headache, insomnia, vertigo, tremor, depression

CV: hypotension, tachycardia

GI: nausea, vomiting, epigastric distress

Hematologic: eosinophilia, leukopenia

Respiratory: asthma attacks

Skin: flushing (especially of face), rash, pruritus, erythema multiforme

Other: hiccups, fever, psychological drug dependence, anaphylactic shock

Interactions

Drug-drug.Antihistamines, opioids, sedative-hypnotics: additive CNS depression

Drug-diagnostic tests.Eosinophils: increased count

Drug-herbs.Chamomile, hops, kava, skullcap, valerian: increased CNS depression

Drug-behaviors.Alcohol use: increased CNS depression

Patient monitoring

• When giving to breastfeeding patient, watch for signs of sedation and GI upset in infant.
• Monitor range of motion, stiffness, and discomfort level.
• Know that drug is metabolized to meprobamate. Monitor for drug dependence, especially in patients with history of substance abuse.

Patient teaching

• Tell patient that psychological drug dependence may occur.
• Instruct patient to avoid over-the-counter drugs and alcohol, because they may increase CNS depression.
• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.
• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, herbs, and behaviors mentioned above.

carisoprodol

/car·iso·pro·dol/ (kar″i-so-pro´dol) an analgesic and skeletal muscle relaxant used to relieve symptoms of acute painful skeletomuscular disorders.

carisoprodol

[ker′isōprō′dol]
a skeletal muscle relaxant.
indication It is prescribed for the relief of muscle spasm.
contraindications Porphyria or known hypersensitivity to this drug or to chemically similar drugs, such as meprobamate, prohibits its use.
adverse effects Among the more serious adverse reactions are ataxia, drowsiness, pronounced weakness, visual disturbances, mental confusion, anaphylactic shock, erythema multiforme, and allergic reactions.

carisoprodol

Rela® Pharmacology A muscle relaxant related to meprobamate. See Meprobamate.

carisoprodol

A centrally-acting muscle relaxant drug used in the treatment of muscle spasms. A brand name is Carisoma.

carisoprodol (ker´īsōprō´dol),

n brand names: Soma, Vanasom;
drug class: skeletal muscle relaxant, central acting;
action: nonspecific central nervous system sedation;
uses: adjunct for relief of muscle spasm in musculoskeletal conditions.