guanylate cyclase

(redirected from Soluble guanylyl cyclase)

guan·y·late cy·clase

(gwahn'i-lāt sī'klās),
An enzyme analogous to adenylate (adenylyl) cyclase, but cyclizing guanosine 5'-triphosphate to guanosine 3':5'-cyclic monophosphate and also producing pyrophosphate; activated by nitric oxide.

guanylate cyclase

enzyme catalyzing the synthesis of 3′5′ cyclic-GMP from GTP in photoreceptor cells of the retina in its dark state. cGMP binds to Na+-channels of the retinal cells, causing them to open.
References in periodicals archive ?
2]) were involved in the relaxing effect of SC, endotheliumintact rings were incubated with L-NAME (a NO synthase inhibitor; 100 [micro]M), MB (a soluble guanylyl cyclase inhibitor; 10 [micro]M), Rp-cAMP (a cAMP antagonist; 10 [micro]M), or Indomethacin (INDO; a non-selective inhibitor of cyclooxygenase, 10 [micro]M) for 60 min prior to the application of PE, respectively.
Cell-specific expression and immunolocalization of nitric oxide synthase isoforms and soluble guanylyl cyclase alpha1 and beta1 subunits in the ovary of fetal neonatal and immature pigs.
Additionally, the involvement of the nitric oxide pathway was also investigated by pretreating the mice with a nitric oxide synthase inhibitor, a nitric oxide donor, a soluble guanylyl cyclase enzyme inhibitor or an ATP-sensitive K+channel blocker 15 minutes prior to rhodiola administration.
Sub-second kinetics of the nitric oxide receptor, soluble guanylyl cyclase, in intact cerebellar cells.
2 The precise mechanism of action is not yet clear, but it appears that HU increases nitric oxide levels, causing soluble guanylyl cyclase activation with a resultant rise in cyclic GMP, and the activation of gamma-globin synthesis necessary for HbF.
Binding of NO to the heme moiety of soluble guanylyl cyclase activates the guanylyl cyclase (GC), which increases the concentration of cyclic Guanosine 3'-5' monophosphate (cGMP).
In general, NO is thought to interact with the iron-containing enzymes, such as soluble guanylyl cyclase (sGC) (Ignarro et al.
Since ODQ interferes directly with soluble guanylyl cyclase activated by NO (22), relaxation induced by ayanin may be related to the production of NO, resulting in an increase of the cGMP in the endothelium.
cGMP mediates the vascular and platelet actions of nitric oxide: confirmation using an inhibitor of the soluble guanylyl cyclase.
To establish the pharmacological concentrations necessary to stimulate cytosolic cGMP production in freshwater shrimp chromatophores, we generated dose-response curves for the soluble guanylyl cyclase activators sodium nitroprusside (SNP) and morpholinosydnonimine (SIN-1), which are nitric oxide donors (Fig.
The proangiogenic activity of NO is mediated by activation of soluble guanylyl cyclase.