heparin

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heparin

 [hep´ah-rin]
1. an acid mucopolysaccharide present in many tissues, especially the liver and lungs, and having potent anticoagulant properties. It also has lipotrophic properties, promoting transfer of fat from blood to the fat depots by activation of the enzyme lipoprotein lipase.
2. a mixture of active principles capable of prolonging blood clotting time, obtained from domestic animals; used in the prophylaxis and treatment of clotting disorders, such as thrombophlebitis, pulmonary embolism, disseminated intravascular coagulation, acute myocardial infarction, or stroke syndrome, and to prevent clotting during extracorporeal circulation, blood transfusion, and blood sampling.
heparin lock a type of intermittent intravenous device for the administration of heparin. It does not require a continuous flow of fluids; the intravenous fluid flow can be disconnected and the heparin lock filled with a heparin solution that maintains patency of the needle.
Two types of heparin or saline lock sets. From Lammon et al., 1995.

hep·a·rin

(hep'ă-rin),
An anticoagulant principle that is a component of various tissues (especially liver and lung) and mast cells in humans and several mammalian species; its principal and active constituent is a glycosaminoglycan composed of d-glucuronic acid and d-glucosamine, both sulfated, in 1,4-α linkage, of molecular weight between 6,000 and 20,000. In conjunction with a serum protein cofactor (the so-called heparin cofactor), heparin acts as an antithrombin and an antiprothrombin. Synthetic preparations are commonly used in therapeutic anticoagulation. It also enhances activity of "clearing factors" (lipoprotein lipases).
Synonym(s): heparinic acid

heparin

/hep·a·rin/ (hep´ah-rin) a sulfated glycosaminoglycan of mixed composition, released by mast cells and by blood basophils in many tissues, especially the liver and lungs, and having potent anticoagulant properties. It also has lipotrophic properties, promoting transfer of fat from blood to the fat depots by activation of lipoprotein lipase. It is used as the calcium or sodium salt in the prophylaxis and treatment of disorders in which there is excessive or undesirable clotting and to prevent clotting during extracorporeal circulation, blood transfusion, and blood sampling.

heparin

(hĕp′ər-ĭn)
n.
An acidic glycosaminoglycan found especially in lung and liver tissue and having the ability to slow the clotting of blood, used as a drug in the treatment of thrombosis.

heparin

[hep′ərin]
Etymology: Gk, hēpar, liver
a naturally occurring mucopolysaccharide that acts in the body as an antithrombin factor to prevent intravascular clotting. The substance is produced by basophils and mast cells, which are found in large numbers in the connective tissue surrounding capillaries, particularly in the lungs and liver. In the form of sodium salt, heparin is used therapeutically as an anticoagulant. See also heparin sodium.

heparin

Hematology A sulfated glycosaminoglycan anticoagulant that inhibits activated factors IXa, Xa, XIa, XIIa and thrombin, ↓ local anti-thrombin-III, promoting its inactivation by neutrophil elastase; interaction of heparin with endothelial cells results in displacement of platelet factor 4, which inactivates heparin Indications Thromboembolism, CAD, post acute MI, PTE Monitoring Titrate heparin so that aPTT is 1.5-2.0-fold normal Side effects Hemorrhage, thrombocytopenia, osteoporosis, skin necrosis, alopecia, hypersensitivity, hypoaldosteronism. See Low-molecular weight heparin.

hep·a·rin

(hep'ăr-in)
An anticoagulant that is a component of various tissues (especially liver and lung) and mast cells. Its principal active constituent is a glycosaminoglycan composed of d-glucuronic acid and d-glucosamine. In conjunction with a serum protein cofactor (the so-called heparin cofactor), heparin acts as an antithrombin and an antiprothrombin by preventing platelet agglutination and consequent thrombus formation.

heparin

A complex polysaccharide organic acid found mainly in lung and liver tissue. Heparin is thought to bind to THROMBIN and antithrombin in plasma thereby assisting in their combination and interfering with the cascade of reactions that end in blood clotting (coagulation). From the Greek hepar , the liver. The drug is on the WHO official list. Heparin is widely used as an anticoagulant under brand names such as Calciparine, Canusal, Hepsal, Monoparin and Multiparin. See also LOW MOLECULAR WEIGHT HEPARIN.

heparin

a mucopolysaccharide molecule produced in the liver and some white blood-cells that acts as an anticoagulant, inhibiting the transformation of prothrombin to thrombin, a vital stage in BLOOD CLOTTING.

Heparin

An organic acid that occurs naturally in the body and prevents blood clots. Heparin is also made synthetically and can be given as a treatment when required.

heparin

endogenous, short-acting anticoagulant that prevents platelet agglutination and thrombus formation; used as a continuous infusion in the treatment of deep venous thrombosis (DVT)
  • low-molecular-weight heparin longer-acting heparin derivatives, e.g. Fragmin 2500 units (used as subcuticular injection 1-2 hours before orthopaedic surgery, and thence daily for 5-7 days) to minimize postoperative DVT, or as 5000 unit injections daily (as treatment of DVT)

heparin

an acid mucopolysaccharide present in many tissues, especially the liver and lungs, and having potent anticoagulant properties. It also has lipotrophic properties, promoting transfer of fat from blood to the fat depots by activation of lipoprotein lipase. Also, a mixture of active principles capable of prolonging blood clotting time, obtained from domestic animals; used in the prophylaxis and treatment of disorders in which there is excessive or undesirable clotting and as a preservative for blood specimens.
References in periodicals archive ?
Control samples performed as anticipated: all clotted samples failed to produce metaphase cells and all specimens collected in sodium heparin produced metaphase cells sufficient for analysis.
The early years--use of liquid sodium heparin solution
1) Specifically, sodium heparin is not known to affect the determination of digoxin, nor are EDTA or citrate.
During a study examining mitogen-induced proinflammatory cytokine production, we discovered that 5-mL glass sodium heparin Vacutainer Tubes (lot no.
We lysed 1 [micro]L of human whole blood that had been drawn into tubes containing dipotassium EDTA, sodium citrate, or sodium heparin as anticoagulant for 1 min at room temperature in a 100-[micro]L final volume of 200 mmol/L NaCl, 10 mL/L Triton [chi]-100, and 2.
02mg/dl in serum or plasma samples including EDTA, lithium heparin, and sodium heparin.
Adiponectin concentrations in samples processed 0, 24, and 36 h after blood collection in EDTA and sodium heparin.
We compared 89 matched samples drawn into serum, EDTA plasma, LiHep plasma, and sodium heparin (NaHep) plasma tubes.