Sneddon's Syndrome is a systemic disease characterized by livedo reticularis and cerebrovascular lesions.
The patient was diagnosed with Sneddon's syndrome based on historical, clinical and laboratory findings and antiaggregant therapy was initiated.
In this case report, we aimed to discuss clinical manifestations, pathological findings in the skin lesions and neuroradiological findings in a patient with antiphospholipid-antibody-negative Sneddon's syndrome and wanted to share our treatment approach.
Key words: Sneddon's Syndrome, generalized livedo reticularis, cerebrovascular lesion, autoantibodies
A case of Sneddon's syndrome with positive ANA and Anti-cardiolipin antibodies: Primary antiphospholipid syndrome?
Sneddon's syndrome (livedo reticularis and cerebrovascular lesions) with antiphospholipid antibodies and severe dementia in a young man: a case report 1994; 89:143-146.
Gradually progressive dementia without discrete cerebrovascular events in a patient with Sneddon's syndrome.
Neurologic Dermatologic Cerebrovascular accident Livedo reticularis Transient ischemic attack Leg ulcers Severe migraine Necrotizing purpura Chorea Distal cutaneous ischemia/ Seizures gangrene Multi-infarct dementia Widespread cutaneous necrosis Ischemic encephalopathy Peripheral neuropathy Obstetric Myasthenia gravis Recurrent fetal loss Sneddon's syndrome Intrauterine growth retardation Preeclampsia Cardiovascular Chorea gravidarum Myocardial infarction Postpartum syndrome Valvular lesions, mitral and aortic Miscellaneous Pseudoinfective endocarditis Avascular necrosis Intracardiac mass Nonthromboembolic pulmonary hypertension Hematologic Thrombocytopenia Coombs' positive hemolytic anemia Leukopenia
20) There is a marked association of aPL in patients with Sneddon's syndrome, an interesting neurological disease consisting of cerebral ischemia with livedo reticularis.