Further, the domains of the oligonucleotide are independent so transcript binding and U1 snRNP
binding can be independently optimized and adapted to a wide array of genes associated with disease.
Lupuzor[TM] corresponds to the sequence 131-151 of the 70k snRNP
protein with a Serine phosphorylated in position 140.
The CBC-mediated interaction between U1 snRNP
and the 5' splice site is one of the earliest steps in spliceosome assembly and is conserved in humans and yeast.
For the amplification of nuclear snRNP
UlA DNA, a primer set was developed with one of the primers in an intron and the other in the adjacent exon sequence.
Steitz has initiated important discoveries in the field of molecular biology, particularly as it pertains to the actions of small RNA(ribonuclie acid) molecules known as snRNP
(small nuclear ribonucleoproteins) involved in regulating gene expression or the transformation of DNA into protein.