CCL8

(redirected from Small-inducible cytokine A8)

CCL8

A gene on chromosome 17q11.2-q12 that encodes monocyte chemotactic protein 2 (MCP-2), a secreted chemokine that is chemotactic for monocytes, lymphocytes, basophils and eosinophils. MCP-2/CCL8 is structurally related to the CXC subfamily of cytokines, and characterised by two cysteines separated by a single amino acid. MCP-2/CCL8 inhibits the chemotactic effect of CCL7, as well as CCL2, CCL5 and CCL8; it may play a role in neoplasia and inflammatory host responses.
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