small cell

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small cell

a short, bluntly spindle-shaped cell that contains a relatively large, hyperchromatic nucleus, frequently observed in some forms of undifferentiated bronchogenic carcinoma.
Synonym(s): oat cell

small cell

A 9–14-µm-diameter cell, with a faint or indistinct rim of cytoplasm and an oval-to-elongated nucleus with relatively dense chromatin. Small cells are “classically” poorly differentiated or undifferentiated neuroendocrine, which is confirmed by presence of cytokeratin and synaptophysin, and/or chromogranin; when a vague “crease” in the nucleus is also present, the descriptor “oat cell” was used in the past, a distinction of uncertain value. Small cells are seen in small-cell carcinomas, which are most common in lungs but also occur in bladder, breast, cervix, ovary, endometrium and nasopharynx.

DiffDx
Non-epithelial lesions with small cells include sarcomas (Ewing sarcoma, rhabdomyosarcoma of alveolar and embryonal types, granulocytic sarcoma, reticulum cell sarcoma and liposarcoma), Wilms’ tumour, neuroblastoma, lymphoma and plasmacytoma.

small cell

Oncology A 9-14 µm in diameter cell with a faint or indistinct rim of cytoplasm, and an oval-to-elongated nucleus with relatively dense chromatin; SCs are 'classically' neuroendocrine–confirmed by presence of cytokeratin and secretory granules; when a vague 'crease' in the nucleus is also present, the descriptor 'oat cell' may be used; SCs occur in small cell carcinomas (duh!), common in lungs, but also occur in bladder, breast, cervix, endometrium, nasopharynx. See Small cell carcinoma.

small cell

(smawl sel)
A short, blunt, spindle-shaped cell that contains a relatively large hyperchromatic nucleus; frequently observed in some forms of undifferentiated bronchogenic carcinoma.
References in periodicals archive ?
6] The presence of circulating small cell lymphoma cells does not impart a poorer prognosis but does correlate with the extent of dissemination, as 90% of Ann Arbor stage III and IV have circulating lymphoma cells.
Most T cell lymphomas are of intermediate grade (diffuse mixed small cell lymphomas, diffuse mixed large cell lymphomas, and diffuse large cell lymphomas) and high grade (large cell immunoblastic lymphomas).
6) According to a recent review of lymphoid proliferations of salivary glands, approximately one third of salivary lymphomas are of the large B-cell type, one third are follicular lymphomas, and one third are low-grade, small cell lymphomas, usually of the mucosa-associated lymphoid tissue type.