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Sirtuin |
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Sirtuin Any of a class of proteins that possess either histone deacetylase—more commonly—or mono-ribosyltransferase activity, named after Sir2, the cell-regulating yeast gene silent mating-type information regulation 2. Sirtuins regulate critical biological pathways in eubacteria, archaea and eukaryotes. Sirtuins influence ageing, transcription, apoptosis, stress resistance, and affect energy efficiency and alertness during hypoglycaemia Most sirtuins are protein deacetylases in which sirtuin-mediated deacetylation couples lysine deacetylation to NAD hydrolysis—instead of simple hydrolysis of acetyl-lysine residues—yielding O-acetyl-ADP-ribose, the deacetylated substrate and nicotinamide. The dependence of sirtuins on NAD links their enzymatic activity directly to the energy status of the cell via the cellular NAD:NADH ratio, the absolute levels of NAD, NADH or nicotinamide or a combination of these variables. Want to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit the webmaster's page for free fun content. |
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No references found | NAD+ is known to play a key role in human cells by activating proteins called sirtuins that help the cells survive under stress. and recently researchers at Harvard Medical School have discovered what they beleive to be an anti aging gene, which is part of a family of enzymes known as sirtuins appear to extend lifespan rather dramatically in organisms like yeast, worms and flies According to their latest work, published in the November 28th issue of the journal Cell, sirtuin is the gene that contributes to aging in single cell organisms like yeast, as well as multiple celled organisms? [ILLUSTRATION OMITTED] The specific molecules that were being conserved turn out to be members of a protein family called the sirtuins (for silent information regulators), which are activated by caloric restriction. |
Sirtuins |
SIRRA sirrah sirrahs SIRRC sirree sirree Sirri Yircali Anadolu Lisesi SIRRM SIRRO SIRS SIRS SIRS SIRS SIRSA Sirt Sirt Sirt4 SIRTA Sirtal Sirtal Sirtal Sirte Oil Company SIRTEL SIRTF SIRTI SIRTOA SIRTS SIRTS Sirtuin Sirtuin-Activating Compound Sirtuins SIRUSIRUF sirup sirup sirup SIRUP Ontology Query API Siruped sirups sirups sirups sirupy SIRUS Sirush SIRV sirvente sirvente sirventes sirventes Sirventesc SIRVES Sirvintos SIRW SIRWA Sirwah SIRWCD SIRy sis sis sis sis | |||||||
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