sirtuins


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Related to sirtuins: resveratrol

sirtuins

Enzymes that appear to be important in the biochemical processes that relate calorie intake restriction to vitality and longevity. See also RESVERATROL.
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Sirtuins that are activated by resveratrol require NAD+ as their energy substrate.
Class III histone deacetylase (HDAC) is also known as sirtuins (SIRTs), and the mammalian SIRT family has seven members (SIRT1-SIRT7).
Scientists believed that modulating Sinclair's sirtuins family of genes and P-53 genes could alter the ageing pre-markers, including the stem cell population in the bone marrow, the high-density lipoproteins and insulin levels, to provide a longer and healthy life.
Matthew says that while sirtuins are involved in a number of the body's cellular processes, including metabolism and ageing, there is no compelling scientific proof that the Sirtfood Diet works by any other means than cutting calories.
Sirtfoods, foods that will affect sirtuin genes, are the latest fad in nutrition science.
Sirtuins are protein deacetylases that are thought to play evolutionarily conserved roles in lifespan extension [92-94].
Deacetylase activity is the major characteristic of Sirtuins response to the balance of cellular energy and requires NAD [sup]+ as the acceptor of an acetyl group from a target acetyl-lysine residue.
Resveratrol, a compound found in red wine, mimics calorie restriction by activating the sirtuins and extending the healthy lifespan of animals.
Her current work contributes to the understanding of how mitochondrial sirtuins regulate tumor cell metabolism.
The researchers found that ApoE4 causes a dramatic reduction in SirT1, which is one of seven human Sirtuins.
Sirtuins are silencing information regulating enzymes which are activated under low cellular energy signals.
Subsequent chapters discuss mitochondria, telomeres, the FoxO transcription factors and sirtuins, insulin and insulin-like growth factor, oxidative stress, mental stress, sleep, inflammation, adipose tissue, weight loss and diet, skeletal muscle and exercise, lipids and atherogenic dyslipidemia, the endothelium and cardiovascular disease, and insulin resistance, metabolic syndrome, and therapy.