Sin Nombre virus
and rodent species diversity: a test of the dilution and amplification hypotheses.
Among the New World hantaviruses (Sin nombre virus
, Andes, Bayou, Black Creek Canal, New York, and Monongahela), Sin nombre virus
(SNV) was first described in 1993 as the cause of a cluster outbreak of severe pneumonia with respiratory failure or hantavirus pulmonary syndrome (HPS) in 24 young patients--18 of whom died (CFR = 76%) --in the Four Corners region of the southwestern US, where the borders of Arizona, Colorado, New Mexico, and Utah meet.
Natural history of Sin Nombre virus
in western Colorado.
Sin Nombre virus
infection of deer mice in Montana: characteristics of newly infected mice, incidence, and temporal pattern of infection.
Summary of laboratory-confirmed hantavirus pulmonary syndrome cases caused by viruses other than Sin Nombre virus
, United States, 1993-2007 No.
Complete genetic characterization and analysis of isolation of Sin Nombre virus
Rapid and specific detection of Sin Nombre virus
antibodies in patients with hantavirus pulmonary syndrome by a strip immunoblot assay suitable for field diagnosis.
Characteristics of patients tested for IgG against Sin Nombre virus
, central Bolivia * No.
In the United States, most HPS cases are likely caused by Sin Nombre virus
(6), the virus responsible for the initially identified HPS cases.
The respiratory form of the disease was described in June 1993 during an epidemic of severe respiratory disease caused by Sin Nombre virus
in the United States (3).
These samples were tested by IgM capture with inactivated Sin Nombre virus
antigens and by indirect ELISA with recombinant antigens to detect IgG antibodies to Sin Nombre virus
In North America, Sin Nombre virus
(SNV) is responsible for most cases of HCPS, and the deer mouse (Peromyscus maniculatus) is its main reservoir.