Current smokers displayed significantly less Parkinsonism (Lower Simpson-Angus Scale scores) but higher levels of akathisia (higher Barnes Akathisia Rating Scale Scores).
Smokers displayed significantly less antipsychoticinduced Parkinsonism as measured by the Simpson-Angus Scale.
In addition, 7% experienced treatment-emergent extrapyramidal symptoms as defined by a Simpson-Angus Scale
score of 3 or less at baseline rising to greater than 3 on treatment.
Extrapyramidal symptoms were evaluated using the Simpson-Angus scale
(Simpson and Angus 1979), Barnes Akathisia scale (Barnes 1989), and abnormal involuntary movement scale (AIMS) (National Institute of Mental Health 1976b).
Participants will be randomized to 100 mg/day of amisulpride or placebo for 12 weeks, with the primary outcomes being change in the Brief Psychiatric Rating Scale, a quality of life measure, and the Simpson-Angus Scale
of Parkinsonian symptoms.
At the same time, they assessed adverse events using the Simpson-Angus Scale
, Barnes Akathisia Rating Scale, and the Abnormal Involuntary Movement Scale.