endometrial hyperplasia

(redirected from Simple hyperplasia)

endometrial hyperplasia

increase in the number of endometrial glands, usually secondary to hyperestrinism; classified as simple hyperplasia, complex hyperplasia, or complex hyperplasia with atypia; the latter may progress to adenocarcinoma.

endometrial hyperplasia

an abnormal condition characterized by overgrowth of the endometrium resulting from sustained stimulation by estrogen (of endogenous or exogenous origin) that is not opposed by progesterone. Estrogen acts as a growth hormone for the endometrium. Through a complex intercellular mechanism, endometrial cells bind estrogen preferentially and undergo changes characteristic of the proliferative phase of the menstrual cycle. If estrogen stimulation continues for 3 to 6 months without periodic cessation or counteractive progesterone stimulation, as occurs in anovulatory or perimenopausal women and in those receiving replacement estrogen without added progestogen, the endometrium becomes abnormally thickened and glandularized. Unremitting estrogen stimulation eventually causes cystic or adenomatous endometrial hyperplasia. The latter is a premalignant lesion that undergoes malignant degeneration in approximately 25% of cases. The causative relationship between estrogen and endometrial hyperplasia is well established; there is some indication but no proof that estrogen also provokes the change from hyperplasia to neoplasia and malignancy. Endometrial hyperplasia often results in abnormal uterine bleeding. Such bleeding, particularly in older women, constitutes an indication for biopsy or curettage of the endometrium to establish histopathological diagnosis and to rule out malignancy. A functioning estrogen-secreting tumor is suspected if the woman is not taking estrogen medication. Progestogen therapy is effective in reversing the abnormal histopathological changes of endometrial hyperplasia. If hyperplasia is adenomatous, hysterectomy is commonly performed.

endometrial hyperplasia

Adenomatous hyperplasia of endometrium Gynecology A premalignant endometrial lesion of older ♀
Endometrial hyperplasia
Hyperplasia without atypia Glands are crowded w/o cytologic atypia; these have a < 2% progress to carcinoma
Simple hyperplasia Glands are not back-to-back
Complex hyperplasia Glands are back-to-back
Hyperplasia with atypia Glands are crowded with cytologic atypia; ± 23% progress to carcinoma

en·do·me·tri·al hy·per·pla·si·a

(en'dō-mē'trē-ăl hī'pĕr-plā'zē-ă)
Increase in the number of endometrial glands, usually secondary to hyperestrinism; classified as simple hyperplasia, complex hyperplasia, or complex hyperplasia with atypia; the latter may progress to adenocarcinoma.
References in periodicals archive ?
Simple hyperplasia of reactive mesothelium is usually not confused with malignancy and, as the name implies, consists of a single row of regularly spaced, cytologically bland, cuboidal mesothelial cells along the pleural surface (Figure 3).
Some studies have suggested that they represent more of a hamartoma or simple hyperplasia than a true neoplastic lesion) Most isolated neurofibromas in the oral cavity are sessile, (5,7) unlike the lesion in our patient, which was pedunculated and mushroom-like.
In a series of 2,052 diagnostic hysteroscopies for abnormal uterine bleeding between 1990 and 2000, 42 women whose endometrial biopsies showed questionable hyperplasia underwent hysteroscopic endomyometrial resection--25 with simple hyperplasia, 7 with complex hyperplasia, and 10 with atypical hyperplasia.
There were specimens obtained from 13 patients with normal proliferative endometrium, 11 with normal secretory endometrium, 26 with simple hyperplasia, 21 with complex hyperplasia with and without atypia, and 37 with endometrioid adenocarcinoma.
Cyclin D1 staining was evaluated in the glandular epithelium component and in the superficial epithelium component (except carcinoma cases) in each group of proliferative endometrium, secretory endometrium, simple hyperplasia, complex hyperplasia, and adenocarcinoma.
84) or among proliferative, secretory, and simple hyperplasia (P = .
24); similarly, there was no difference among proliferative, secretory, and simple hyperplasia (P = .
Our findings support the significance of complex hyperplasia as a precancerous lesion, but apparently do not support the notion that simple hyperplasia is precancerous.

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