endometrial hyperplasia

(redirected from Simple hyperplasia)

endometrial hyperplasia

increase in the number of endometrial glands, usually secondary to hyperestrinism; classified as simple hyperplasia, complex hyperplasia, or complex hyperplasia with atypia; the latter may progress to adenocarcinoma.

endometrial hyperplasia

an abnormal condition characterized by overgrowth of the endometrium resulting from sustained stimulation by estrogen (of endogenous or exogenous origin) that is not opposed by progesterone. Estrogen acts as a growth hormone for the endometrium. Through a complex intercellular mechanism, endometrial cells bind estrogen preferentially and undergo changes characteristic of the proliferative phase of the menstrual cycle. If estrogen stimulation continues for 3 to 6 months without periodic cessation or counteractive progesterone stimulation, as occurs in anovulatory or perimenopausal women and in those receiving replacement estrogen without added progestogen, the endometrium becomes abnormally thickened and glandularized. Unremitting estrogen stimulation eventually causes cystic or adenomatous endometrial hyperplasia. The latter is a premalignant lesion that undergoes malignant degeneration in approximately 25% of cases. The causative relationship between estrogen and endometrial hyperplasia is well established; there is some indication but no proof that estrogen also provokes the change from hyperplasia to neoplasia and malignancy. Endometrial hyperplasia often results in abnormal uterine bleeding. Such bleeding, particularly in older women, constitutes an indication for biopsy or curettage of the endometrium to establish histopathological diagnosis and to rule out malignancy. A functioning estrogen-secreting tumor is suspected if the woman is not taking estrogen medication. Progestogen therapy is effective in reversing the abnormal histopathological changes of endometrial hyperplasia. If hyperplasia is adenomatous, hysterectomy is commonly performed.

endometrial hyperplasia

Adenomatous hyperplasia of endometrium Gynecology A premalignant endometrial lesion of older ♀
Endometrial hyperplasia
Hyperplasia without atypia Glands are crowded w/o cytologic atypia; these have a < 2% progress to carcinoma
Simple hyperplasia Glands are not back-to-back
Complex hyperplasia Glands are back-to-back
Hyperplasia with atypia Glands are crowded with cytologic atypia; ± 23% progress to carcinoma

en·do·me·tri·al hy·per·pla·si·a

(en'dō-mē'trē-ăl hī'pĕr-plā'zē-ă)
Increase in the number of endometrial glands, usually secondary to hyperestrinism; classified as simple hyperplasia, complex hyperplasia, or complex hyperplasia with atypia; the latter may progress to adenocarcinoma.
References in periodicals archive ?
In a study by Vaidya et al, simple hyperplasia without atypia was in 1.
These included proliferative phase,disordered proliferative endometrium,irregular maturation of endometrium, discordance between stroma and glands, simple hyperplasia and complex hyperplasia (table 2).
9%) cases out of which simple hyperplasia without atypia was seen in 19, complex hyperplasia without atypia in 4 and complex hyperplasia with atypia in 1 case.
This approach overlooks such realities as the increased incidence of simple hyperplasia in many perimenopausal women, which appears to regress with further reduction in ovarian estrogen.
In comparison to the four categories (simple hyperplasia, complex hyperplasia, simple hyperplasia with atypia, and complex hyperplasia with atypia) that comprise the World Health Organization (WHO) 1994 classification system, proponents of the BH/EIN classification system have shown improved reproducibility in the diagnostic setting.
Only one patient was reported atypical and others histopathology was simple hyperplasia.
Histological evaluation confirmed the polyps as simple hyperplasia of the endometrium in each case.
Some studies have suggested that they represent more of a hamartoma or simple hyperplasia than a true neoplastic lesion) Most isolated neurofibromas in the oral cavity are sessile, (5,7) unlike the lesion in our patient, which was pedunculated and mushroom-like.
In a series of 2,052 diagnostic hysteroscopies for abnormal uterine bleeding between 1990 and 2000, 42 women whose endometrial biopsies showed questionable hyperplasia underwent hysteroscopic endomyometrial resection--25 with simple hyperplasia, 7 with complex hyperplasia, and 10 with atypical hyperplasia.
3% each with simple hyperplasia and simple hyperplasia with atypia.
6 These are: Simple hyperplasia without atypia; Complex hyperplasia without atypia; Simple hyperplasia with atypia; and Complex hyperplasia with atypia.
9%, of which simple hyperplasia (figure 3) was the most common (35.

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